Вирусная инфекция и метаболизм холестерина в макрофагах

Автор: Букринский М.И., Карагодин В.П., Свиридов Д.Д., Орехов А.Н.

Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk

Статья в выпуске: 1-1 т.26, 2011 года.

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Макрофаги играют центральную роль в патогенезе атеросклероза и являются хозяином для ряда вирусов. Холестерин также играет ключевую роль в реакциях врожденного иммунного ответа против вирусной инфекции. Хотя ослабление врожденного иммунного ответа за счет увеличения содержания холестерина в клетке может быть преднамеренной стратегией, используемой вирусами для повышения патогенной эффективности, рост риска атеросклероза может быть побочным продуктом этого. В обзоре описаны различные механизмы, позволяющие вирусам использовать метаболизм холестерина в макрофагах, отбирая холестерин либо на цели увеличения вирусной репликации и/или изменяя врожденный иммунный ответ. Дальнейшее выяснение механизмов связи вирусных инфекций с метаболизмом холестерина в макрофагах может быть полезным для разработки подходов к лечению как атеросклероза, так и вирусных заболеваний.

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Макрофаги, атеросклероз, холестерин, вирусные инфекции

Короткий адрес: https://sciup.org/14919392

IDR: 14919392

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