The contribution of genetic polymorphism to the formation of excess body weight in coal mine workers

Nutrigenetic status characterizes inherited variants of genes that control nutrient metabolism and eating behavior, and therefore determine the risks of diet-related diseases. It takes on particular importance in production groups. For example, among miners, the nutritional factor can significantly influence the body's adaptation mechanisms to the effects of unfavorable production factors. The purpose of this work was to analyze the distribution of polymorphic variants of genes that control the metabolism of lipids, carbohydrates and eating behavior and its relationship with body mass index in a group of active coal mine workers. 158 miners of the Sibirskaya coal mine (Polysayevo, Kuzbass, Russia) were examined. Polymorphic variants of genes were studied using real-time polymerase chain reaction: FABP2 (rs1799883, c.163A>G, p.Thr55Ala), ADRB3 (rs4994 c.190T>C, p.Trp64Arg), ADRB2 (rs1042713 c.46G>A , p.Gly16Arg), PPARG (rs1801282, c.34C>G, p.Pro12Ala), APOB (rs5742904, c.10580G>A, p.Arg3527Gln), APOE (rs429358 c.388T>C and rs7412 c.526C> T), TCF7L2 (rs12255372 c.552+9017G>T and rs7903146 c.450+33966C>T), ANKK1 (rs1800497, c.2137G>A, p.Glu713Lys), LEPR (rs1137100, c.326A>G, p .Lys109Arg), FTO (rs9939609, g.53786615T>A).