Effect of antioxidant preparations of different mechanisms of action on the level of lipid peroxidation products in the organism of pregnant sheep

Antioxidant drugs "E-selenium" and Catosal help to reduce LPO processes in the body of pregnant ewes. Were formed 3 groups of animals - analogs, three heads each (control and two experimental). Ewes of experimental group 1 were injected intramuscularly with the preparation "E-selenium" in a dose of 1 ml per head once a month for 2 months, starting from the third month of pregnancy. The animals of the second experimental group in the same periods were injected with the drug "Catosal" intramuscularly at a dose of 4 ml per head once a month for 2 months. The feeding of animals of all groups was the same, balanced in nutrients and corresponded to the norms of the Russian Academy of Agricultural Sciences. The experiment lasted 155 days. There was an increase in the production of DC in the 3rd month of pregnancy in the control group of animals in comparison with the experimental ones, in its so-called "peak", it was significantly higher than in the 1st month, in experimental group 1 by 9.8 %, with experimental group 2 by 9.71%, in control by 18.75 %. During this crucial period, the laying of fruits occurs in the body of ewes, which is reflected in the level of its own antioxidant system. A similar increase can be traced in the case of MDA, which is a secondary oxidation product and is often formed from diene conjugates. The difference in the control group in comparison with the experimental group 1 was 7.48 % and the experimental group 2 13.84 %. Starting from the 4th and 5th months of pregnancy, as the intensity of LPO processes increased, the concentration of DC and MDA production decreased in the experimental groups and especially in the experimental group 2.