The effect of blood platelet-rich plasma comprising an agent for external use on reparative osteogenesis (an experimental study)

Purpose. To study the possibility of influencing the blood platelet-rich plasma (BPRP) lyophylizate on bone reparative regeneration for applying BPRP as a part of an agent for external use. Materials and Methods. The influence of Tizol gel suspension, as well as that of blood platelet-rich plasma (BPRP) lyophylizate of intact donors as a part of an agent for external use on regeneration process after rib osteotomy in recipients (laboratory mice) studied. The similarly diluted BPRP-free Tizol applied to the animals of control group. The cell composition of regeneration zone, and the biochemical values of blood serum in recipients studied ten days after surgery. Results. A lot of cells of osteoblastic differentiation line found in the regenerated bone tissues of the animals in experimental group, as well as fewer cells of chondroblastic differentiation line (441 % and 45 % of control values, respectively). The lower calcium concentration found in blood serum of the animals in experimental group (79 % of control values). Conclusion. The acceleration of regeneration processes concluded for this mode of BPRP using, and the approach proposed to consider this phenomenon mechanisms.