Influence of the chronic psychosocial stress on intensity of degenerate changes in retina at rats with various stress-resistance

At 20 rats it was modeled chronic psychosocial stress within 10 and 18 days, after then studied the signs of retina ganglionic cells apoptosis by TUNEL method and the maintenance of ceramide and sphingomyelin in tissues by method of thin layer chromatography. Comparison with control group (10 rats) is carried out. At a stress the separate TUNEL-the positive nucleus of retina ganglionic cells, which were absent at control animals are found. At a stress-unstable rats signs of degenerate changes of retina (reduction of ganglionic cells quantity), as well as increase the level of ceramide in structures of eyes posterior segment and blood plasma were more expressed, than at stress-steady (by 5,9 times and 4,3 times respectively). The obtained data testify that the psychoemotional stress can promote the development of degenerate changes in retina, in bigger degree at individuals with low resistance to stress.