Effect of oregano and marsh cinquefoil extracts on the behavior of model animals in the "open field" test

The aim of this study was to investigate the effect of oregano (O) and marsh cinquefoil (MC) extracts on the behavioral indices of model animals (laboratory mice) in the open field test. The study was conducted on 54 two-month-old ICR mice of different sexes. For four weeks, mice from the first experimental group received O extract through a drinker, and mice from the second group received MC extract. Behavior was assessed in the open field test, taking into account such indices as the latent time of the animal's exit from the central zone of the arena, the number of sectors crossed separately for the center and periphery of the arena and the total (horizontal activity), the number of vertical rearing (vertical activity) and sniffing of holes in the arena floor, acts of grooming (washing), defecation and urination, and the number of fecal boluses. The results showed that repeated testing in all groups (except for males consuming O extract) revealed a decrease in the latency of the animal's exit from the central area of the arena, a decrease in the number of vertical rearings and total horizontal activity, an increase in the number of grooming acts, defecation, the number of fecal boluses and urination (except for females consuming O extract). Factor analysis was used to isolate factors of motor and emotional activity from behavioral indicators. A significant (F2, 49=2.1 p function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }