The effect of extracts of berries and leaves extracts of black chokeberry (X sorbaronia mitschurinii) on the lifespan of Drosophila melanogaster

Black chokeberry (хSorbaronia mitschurinii) is a valuable fruit crop with a high content of a wide range of polyphenols and other biologically active substances. The fruits contain flavonoids (quercetin, rutin), phenolic acids (neochlorogenic, chlorogenic and caffeic acids), anthocyanins (various cyanidins), as well as vitamins (C, E, B2, B9, P, PP) and minerals (zinc, copper, iron, cobalt). The leaves are dominated by flavonoids (rutin, quercetin) and phenolic acids in the form of caffeic, chlorogenic and rosmarinic acids. It is known that these biologically active substances have geroprotective potential. Previously, we found that short-term use of chokeberry extract from the 4th to the 6th week of life had a positive effect on the lifespan of Drosophila melanogaster. Therefore, we analyzed the effect of fruit extracts (0.01, 0.1, 1, 2.5, 5 and 10 mg/ml) and leaves (0.01, 0.1, 1 and 5 mg/ml) of chokeberry on life expectancy of D. melanogaster when imago was treated from the age of 4 weeks to the end of life It was found that the berry extract at a concentration of 0.1 mg/ml decreased the median and maximum lifespan of males by 7 % and 2 %, respectively, while in females, the extract at a concentration of 1 mg/ml increased the median and maximum lifespan by 5 % and 4 %, respectively. At the same time, the leaf extract decreased the median and maximum lifespan of males. In females, the leaf extract at a concentration of 0.1 mg/ml increased the median lifespan by 2 %, while at a concentration of 0.01 mg/ml it decreased it by 5 %. Thus, further studies of chokeberry fruit and leaf extracts are needed to identify the mechanisms of influence on the adaptive capabilities of both sexes of D. melanogaster.