Influence of immunocompetent cells modulated ex vivo by chlorpromazine on hematopoiesis during aggression

Background. Prolonged stress, including chronic social stress, results in anxiety and aggressive or depression-like behavior. Neuroendocrine signals formed during prolonged social stress cause the activation of myelopoiesis, which is accompanied by increased migration of monocytes from the bone marrow to the periphery and the acquisition of an “inflammatory” Ml-phenotype by them. Some of these monocytes also migrate to the brain, activating endothelial cells and microglia, which leads to the formation of a neuroinflammatory status and behavioral changes. Previously, we obtained priority data on the possibility of editing patterns of aggressive behavior by syngeneic immunocompetent cells modulated ex vivo with chlorpromazine and showed the cytokine-mediated mechanisms of this effect.