The effect of norepinephrine on myocardial contractility in rats with chronic tryptophanhydroxylase blockade in the embryonic period of ontogenesis

The effect of the serotonin synthesis enzyme blocker para-chlorophenyl-alanine (PCPA) in the embryonic period of ontogenesis on the reaction of the left ventricular myocardial contraction force to norepinephrine in early postnatal ontogenesis of rats aged 7 and 14 days was studied. It was found that in rats with a blockade of serotonin synthesis in the embryonic period of ontogenesis, the force of contraction of the left ventricular myocardium was reduced by 50 and 30%, as well as the reaction of the force of myocardial contraction to norepinephrine was 2-8 times less compared to the control group at 7 and 14 days of age.