Influence of oxidative stress on the element status of tissue of organs regulations of mineral homeostasis

The present work is devoted to the study of the elemental composition of the tissues of organs involved in the regulation of the mineral homeostasis of the body - the kidneys, small intestine, distal colon of rats under conditions of glucocorticoid-induced oxidative stress. The development of oxidative stress in animals was initiated by daily, for 14 days, intragastric administration of an aqueous suspension of the synthetic glucocorticoid Prednisolone (Nycomed Austria GmbH, Austria) at a dose of 50 mg / kg. The elemental status of biomaterials was determined by the method of atomic emission analysis with inductively coupled plasma (OPTIMA spectrometer, code of the KHA method: MUK 4.1.1482-03). The content of the following biogenic elements was determined in blood plasma samples and test tissue samples: Na, K, Ca, Mg, Fe, Zn and Cu. It was found that with glucocorticoid-induced oxidative stress, a statistically significant change in the elemental composition of blood plasma, tissues of the small intestine, distal colon and kidneys occurs, which indicates a redox-dependent disturbance in mineral metabolism...