Influence of polysaccharides on morphological indicators of rat blood

The biological safety of the use of chitosan polysaccharide in connection with Se for the body of laboratory animals was studied in this work. Chitosan is an aminopolysaccharide derived from the chitin shells of marine crustaceans. Aminopolysaccharide is a rich source of natural dietary fiber, which binds to fats and removes them in an undigested form from the body. Chitosan is able to bind organic matter through hydrogen bonding and a combination of hydrophobic interactions, making it a good adjuvant as well as an antioxidant. Animals of the experiment - rats were divided into 4 groups: control and three experimental. Initially, the rats were kept in quarantine for 21 days, they received food contaminated with phytotoxins. The rats of the 1st experimental group received a polysaccharide - chitosan at a dose of 0.03 g/kg, the 2nd - chitosan (a dose of 0.03 g/kg) + Se, the 3rd - Se. The control group was kept under generally accepted clinical conditions. Chitosan was received once, in the morning with water. The animals were in the experiment for 45 days, where they were weighed daily, externally examined with control over their behavior, the condition of the outer cover and visible mucous membranes. The paper studied the morphological and biochemical parameters of blood, the data obtained prove that the studied polysaccharide does not adversely affect the body of laboratory animals, but rather normalizes the indicators of internal homeostasis in rats.