Effect of enrofloxacin on dynamics of leukocytic indices in duckling blood

Herein we present the results of the experiment aimed at studying the effect of enrofloxacin on dynamics of leukocytic indices of endogenous intoxication and of indices of non-specific resistance in duckling blood; aforenamed indices indirectly reveal the state of physiological status of birds. We divided the ducklings into 2 groups, Group I was assigned as control (they received pure drinking water), Group II was assigned as experimental (they received enrofloxacin via drinking water at concentration 200 mg/L for 10 consecutive days). Blood samples were drawn at Day 1, Day 3, Day 5, Day 7 and Day 9 after the drug withdrawal. WBC differential was performed and then we calculated index of immunoreactivity (IIR), Krebs index (KI), leukocyte index (LI), lymphocyte-granulocyte index (LGI), leukocyte index of intoxication (LII), leukocyte shift index (LSI). In the course of all the tests we observed reliable changes in practically all the indices on Day 3 and Day 7 after the drug withdrawal, which could be caused by action of enrofloxacin. For instance, indices of endogenous intoxication (LII and LSI) increased on Day 3 (by 34 and 31 % respectively) and on Day 7 (by 72 and 59 % respectively); on the same days LGI decreased reliably by 35 and 70 %, while LI decreased by 37 and 76 % and KI increased by 34 and 68 %. But the changes we registered were not lasting and the change in IIR occurred only once. However, all the registered changes in blood of ducklings in experimental group did not leave reference intervals.