Влияние вязкости плазмы и гематокрита на деформацию эритроцитов

Целью данного исследования было изучение величины вязкости плазмы при разном гематокрите ( Hct ) у практически здоровых доноров – мужчин ( n = 48) и у лиц, страдающих анемией ( n = 18; гемоглобин > 90 г/л и гематокрит > 35%), а также влияние этих реологических характеристик на деформацию эритроцитов. Анализ полученных данных показал, что низкий гематокрит как в норме, так и при анемии сочетается с относительно высокой вязкостью плазмы. Однако оказалось, что низкая вязкость плазмы может сочетаться с большим гематокритом. При этом у лиц с более высокой вязкостью плазмы выявлен на 8% ( p The aim of this study was to investigate the value of the plasma viscosity (PV) under a different hematocrit (Hct) in healthy individuals and anemic patients and to analyze the effect of these rheological characteristics on the erythrocyte microrheological characteristics, mainly their deformation. In order to study the plasma viscosity role in circulation, the whole subject population of (48 normal individuals and 18 anemic patients) into two subgroups with the relative low and high level of PV was divided. The value of hematocrit (Hct) and red blood cell rigidity and deformability were considered under these conditions. The obtained data showed that low Hct both under the normal conditions and the anemia is accompanied by a relative high PV. It has been found that there was lower erythrocyte rigidity index (Tk) in individuals with high PV. There was a moderate negative correlation between the cell rigidity index and PV, whereas the correlation of this microrheological parameter with Hct was positive. Therefore, we can conclude that an increase of plasma viscosity brings into concord a decrease of erythrocyte rigidity and an erythrocyte deformability rise. On the other hand, it can suppose that the hematocrit increase leads to a rise of erythrocyte rigidity and their whole deformation reduction. Taken together, the obtained data have shown clearly that plasma viscosity increase under the conditions of low Hct ensures the needed shear stress on vascular endothelium and contribute heavily to the erythrocyte deformation. Taken together, the obtained data make us believe that the moderate plasma viscosity increase leads to activation of vascular control mechanisms and creation of more effective erythrocyte deformation. Therefore, the tissue perfusion and oxygen transport efficiency under these conditions can be improved.