Intravesical replacement of glycosaminoglycans in patient management with cystitis

Objective: The article presents a review of modern literature on the problem of chronic diseases of the bladder, including painful bladder syndrome/interstitial cystitis, recurrent lower urinary tract infection, chemical or radiation cystitis, the pathogenesis of which is associated with the same pathophysiological changes. Material: The first step in the development of these diseases is associated with the loss of glycosaminoglycans (GAGs) in the mucous membrane of the bladder. The glycosaminoglycan layer consists of negatively charged polysaccharides. The GAG layer binds water, turning it into a gel, using a process known as electrostatic capture. As a result, a buffer is formed between the toxic components of urine and urothelial cells. The GAG thin line acts as a non-specific release factor and non-specific defense mechanism against infection and substances in the urine (for example, urea and potassium). The analysis of modern studies that confirm a decrease in the rate of relapse of urinary tract infections (UTI) due to the replenishment of the GAG line is presented...