Intravascular platelet activity in hypertensive patients with metabolic syndrome under drug-free modalities

Problems of platelet dysfunction correction in patients with arterial hypertension with metabolic syndrome are considered to be a serious challenge in modern clinical medicine. Many antihypertensive drugs belonging to different pharmacological groups were tested in this respect. However, despite the fact that different drug-free modalities constitute the basis form of any metabolic syndrome treatment, many of its aspects are not clarified and the available information is fragmentary. The objective of the paper is to evaluate drug-free modalities in terms of their impact on intravascular platelet activity in patients with arterial hypertension and metabolic syndrome. Materials and Methods. The study enrolled 25 middle-aged patients with arterial hypertension (1st-3rd degree), risk 1-4. The patients demonstrated metabolic syndrome, namely, impaired glucose tolerance, hyperlipidemia type IIb (mild case), abdominal obesity. The control group included 21 healthy persons of the same age. Biochemical, hematological and statistical diagnostic techniques were applied. Results. Combination of hypocaloric diet together with personalized physical load in patients with arterial hypertension and metabolic syndrome gradually reduces shifts in the lipid blood spectrum and peroxidation syndrome, and gradually suppresses the initially high intravascular platelet activity. These indices maximized by the end of the 24th week of treatment, however, they did not reach the target values. Conclusion. Rational diet and personalized physical load have a positive effect on the metabolism and platelet activity in patients with arterial hypertension and metabolic syndrome. However, to improve platelet activity in such patients it is necessary to combine drug-free modalities with pharmaceutical treatment.