The incidence of mastitis in cows and the properties of a new remedy for its therapy

Currently, the problems of udder inflammation in cows and obtaining high-quality dairy products have not lost their relevance. With a slight increase in the breeding stock, the percentage of animals with mastitis in the herd continues to be high. A technology for producing silver nanoparticles (2000 ppm) has been developed. Microbiological studies have shown that native Ag solutions exhibit bactericidal properties to museum strains of E.coli and S.aureus after 24 hours, and in a 1:10 dilution after 48 hours. Dilutions of the Ag solution with glycerin had significantly lower antibacterial properties against E.coli and S.aureus. As part of preclinical studies, it was found that a single dose (1.0 ml) of a solution of nanosilver and a proteolytic enzyme does not cause a fatal outcome in laboratory mice. The use of the drug for two weeks caused hyperchromia and anisocytosis of red blood cells in mice, without any macroscopic changes in internal organs.