Pathogenesis of oxidative stress and endogenous intoxication in the presence of multiple organ dysfunction syndrome in patients with coronary artery disease

We have examined 27 patients with multiple dysfunction syndrome after coronary artery bypass grafting. Endogenous intoxication (EI) level was estimated by middle mass molecules (MMM) concentration, oxidative stress (OS) are fixed by malonic dialdegid (MD), conjugate triens (CT), ceruloplasmin (CP) and catalase activity. Significant intensification of lipid peroxidation and EI were recorded on the first day after surgical intervention. On the 3-4th day after surgical intervention the increasing of EI with high OS was fixed. On the 10-12th day the decreasing of lipid peroxidation and EI were marked. Correlation analysis revealed the direct connection of the indices between MD, CT and MMM-levels. Consequently, lipid peroxidation activization is an important pathogenetic link of endotoxic evolution which in its turn the form level amplifier of oxidative stress activization. CT and MD-level indices can be used as the informative test for appraisal patients with multiple organ dysfunction syndrome after myocardial revascularizaton.