The significance of markers of systemic inflammation in conciliatory recommendations for the treatment of surgical diseases

Introduction. The need for highly sensitive and highly specific markers of systemic inflammation (MI) in most emergency surgical diseases remains an urgent scientific and clinical task.Results. The article is devoted to the description of the main characteristics of the most accessible MI used in abdominal diseases. Thus, in acute appendicitis, it is recommended to assess the level of C-reactive protein and procalcitonin not only for primary diagnostics, but also as a differential criterion between uncomplicated and complicated forms of the disease. The use of MI in patients with suspected acute cholecystitis is even more important than in other acute abdominal diseases, since early stratification of cohorts by disease severity is crucial for the timing and extent of surgical treatment in this patient population. The presence and varying severity of the aseptic inflammation phase, and especially the development of infected acute pancreatitis, leave no other options than to monitor not only vital functions in patients, but also the dynamics of MI concentration. Non-specificity of symptoms, wide variability of clinical and morphological manifestations of intra-abdominal inflammation formed the basis for recommendations on mandatory determination of the level of C-reactive protein in the blood serum of patients with acute diverticulitis.Conclusions. Effective MI should be used in emergency abdominal surgery not only for early verification of the inflammatory genesis of the patient's painful condition, selection of the optimal therapeutic component, but also for prognosis, and especially for monitoring the course of the disease.