Значение витаминов в ангиогенезе

Автор: Шевченко Ю.Л., Борщев Г.Г.

Журнал: Вестник Национального медико-хирургического центра им. Н.И. Пирогова @vestnik-pirogov-center

Статья в выпуске: 3 т.13, 2018 года.

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Цель статьи на основе данных литературы, оценить ангиогенный эффекты витаминов A, B, C, D, E и K и определить их потенциальное использование в качестве про- или антиангиогенных агентов. Показано, что Витамин А: 13-цис-ретиноидная кислота и ациклический ретиноид ингибируют ангиогенез, в то время как транс-ретиноевая кислота оказывает проангиогенные свойства. Витамин B1 - проангиогенное вещество. Витамин B2 ингибирует ангиогенез путем уменьшения фосфорилирования тирозина. Витамин B3 - проангиогенное вещество. Витамин B6 подавляет пролиферацию эндотелиальных клеток и ингибирует ДНК-полимеразу, действуя как антиангиогенное вещество. Витамин B9 снижает синтез ДНК и пролиферации эндотелиальных клеток. Витамин B12 проангиогенный витамин. Витамин С проявляет антиангиогенные свойства путем ингибирования образования NO. Витамин D действует как антиангиогенное вещество посредством индукции клеточного цикла и апоптоза сосудистых и опухолевых клеток. Витамин Е - антиангиогенное вещество. Он ингибирует как пролиферацию, так и образование трубочек из эндотелиальных клеток. Витамин K действует как антиангиогенное вещество через K-зависимый гликопротеин, ингибируя VEGF-R2-зависимую васкуляризацию.

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Ангиогенез, регенерация, витамины a, e и k, аngiogenesis

Короткий адрес: https://sciup.org/140237208

IDR: 140237208 | DOI: 10.25881/BPNMSC.2018.70.46.023

Список литературы Значение витаминов в ангиогенезе

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