Platelet aggregation activity and carriership of allelic variants in genes of platelet glycoprotein receptors in patients with congenital heart diseases with single ventricle defects

Aim: The aim of the study was to analyze the results of genetic testing of platelet glycoprotein receptors and their aggregation activity in patients with congenital heart diseases (CHD) with single ventricle defect (SVD). The study comprised 50 children referred for planned surgical correction of CHD. In all patients, the value of platelet aggregation activity was assessed in the presence of Cardiomagnyl and was compared with the results of genetic testing of platelet receptors for collagen ITGA2:807С>Т and for fibrinogen ITGB3:1565T>C. In study patients, the average levels of platelet aggregation in the presence of collagen inductor were 52.5% in carriers of СС genotype of ITGA2:807 gene, 49.0% in carriers of СT genotype, and 65.1% in children carrying TT genotype. The average levels of platelet aggregation in the presence of epinephrine-inductor were 56.3% and 65.8% in carriers of ТТ and ТС genotypes, respectivley, and did not significantly differ from aggregation I patients with CC genotype: 75.6% (р=0.506). In group of study patients with CHD, no relationships of allelic variants of platelet glycoprotein receptor genes for collagen ITGA2:807С>Т and for fibrinogen ITGB3:1565T>C with platelet aggregation activity level were found. Meanwhile, the absence of changes in platelet aggregation activity in response to collagen and epinephrine was found in 30% and 38% of children with CHD administered with Cardiomagnyl.