Biocompatible implants in orthopedics: bone tissue engineering

Автор: Popkov A.V., Popkov D.A.

Журнал: Гений ортопедии @geniy-ortopedii

Статья в выпуске: 6 т.29, 2023 года.

Бесплатный доступ

Introduction Technological advances in bone tissue engineering have improved orthopaedic implants and surgical techniques for bone reconstruction. This approach allows overcoming inconvenience of the paucity of autologous materials available and donor site morbidity.Aim To demonstrate advances of the past 30 years in the development of bioimplants providing alternatives to bone grafting in reconstructive orthopaedics.Methods Preparing the review, the scientific platforms such as PubMed, Scopus, ResearchGate, RSCI were used for information searching. Search words or word combinations were bioactive osteoinductive implants, bone grafting, bone reconstruction, hydroxyapatite, bone scaffolds.Results The main trends in tissue engineering in the field of orthopaedics are represented by construction of three-dimensional structure implants guiding cell migration, proliferation and differentiation as well as mechanical support. Association with bone morphogenetic proteins, growth factors enables proliferation and differentiation of cell types of the targeted bone tissue. A promising advancement should be biodegradability with a controllable degradation rate to compliment cell/tissue in-growth and maturation in limb reconstruction.Discussion This review presents and discusses the experimental and clinical application of biotolerant, bioinert and bioactive materials for reconstructive bone surgery. Future generations of biomaterials are designed to be osteoconductive and osteoinductive.Conclusion Properties of polycaprolactone (PCL) filled with hydroxyapatite (from 10 to 50 wt %) make this hybrid material with controllable absorption a promising strategy for reconstructive surgery in comparison to other materials.

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Bone tissue engineering, reconstructive orthopedics, clinical translation

Короткий адрес: https://sciup.org/142240039

IDR: 142240039 | DOI: 10.18019/1028-4427-2023-29-6-662-668

Список литературы Biocompatible implants in orthopedics: bone tissue engineering

Shevtsov VI, Popkov AV. Operative lengthening of the lower extremities. M.: Medicine; 1998:192. (In Russ.)
Shevtsov VI. Shved SI, Sysenko YM. Transosseous osteosynthesis in the treatment of comminuted fractures. Kurgan; 2002:331. (In Russ.)
Lascombes P, Popkov D, Huber H, et al. Classification of complications after progressive long bone lengthening: proposal for a new classification. Orthop Traumatol Surg Res. 2012;98(6):629-637. doi: 10.1016/j.otsr.2012.05.010
Curran AR, Kuo KN, Lubicky JP. Simultaneous ipsilateral femoral and tibial lengthening with the Ilizarov method. J Pediatr Orthop. 1999;19(3):386-390.
Vargas Barreto B, Caton J, Merabet Z, et al. Complications of Ilizarov leg lengthening: a comparative study between patients with leg length discrepancy and short stature. Int Orthop. 2007;31(5):587-591. doi: 10.1007/s00264-006-0236-2
Launay F, Jouve JL, Guillaume JM, et al. Les allongements progressifs de l'avant-bras chez l'enfant [Progressive forearm lengthening in children: 14 cases]. Rev Chir Orthop Reparatrice Appar Mot. 2001;87(8):786-795. (In French)
Song HR, Myrboh V, Oh CW, et al. Tibial lengthening and concomitant foot deformity correction in 14 patients with permanent deformity after poliomyelitis. Acta Orthop. 2005;76(2):261-269. doi: 10.1080/00016470510030670
Sluga M, Pfeiffer M, Kotz R, Nehrer S. Lower limb deformities in children: two-stage correction using the Taylor spatial frame. J Pediatr Orthop B. 2003;12(2):123-128. doi: 10.1097/01.bpb.0000049578.53117.03
Stanitski DF, Shahcheraghi H, Nicker DA, Armstrong PF. Results of tibial lengthening with the Ilizarov technique. J Pediatr Orthop. 1996;16(2):168-172. doi: 10.1097/00004694-199603000-00006
Eralp L, Kocaoglu M, Ozkan K, Türker M. A comparison of two osteotomy techniques for tibial lengthening. Arch Orthop Trauma Surg. 2004;124(5):298-300. doi: 10.1007/s00402-004-0646-9
Ielo I, Calabrese G, De Luca G, Conoci S. Recent Advances in Hydroxyapatite-Based Biocomposites for Bone Tissue Regeneration in Orthopedics. Int J Mol Sci. 2022;23(17):9721. doi: 10.3390/ijms23179721
Kaspiris A, Hadjimichael AC, Vasiliadis ES, et al. Therapeutic Efficacy and Safety of Osteoinductive Factors and Cellular Therapies for Long Bone Fractures and Non-Unions: A Meta-Analysis and Systematic Review. J Clin Med. 2022;11(13):3901. doi: 10.3390/jcm11133901
Calcium phosphate-based ceramic and composite materials for medicine. Russian Chemical Reviews. 2010;79(1):13-29. doi: 10.1070/ RC2010v079n01ABEH004098
Chaturvedi TP. An overview of the corrosion aspect of dental implants (titanium and its alloys). Indian J Dent Res. 2009;20(1):91-98. doi: 0.4103/0970-9290.49068
Filip DG, Surdu VA, Paduraru AV, Andronescu E. Current Development in Biomaterials-Hydroxyapatite and Bioglass for Applications in Biomedical Field: A Review. J Funct Biomater. 2022;13(4):248. doi: 10.3390/jfb13040248
Suchanek W, Yoshimura M. Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. Journal of Materials Research.1998;13(1), 94-117. doi: 10.1557/JMR.1998.0015
Steinemann SG. Corrosion of surgical implants - in vivo and in vitro tests, eds. Winter GD, Leray JL, de Goot K. Evaluation of biomaterials, advances in biomaterials. Chichester: Wiley; 1980;1:1-34.
Thull R. Titan in der Zahnheikunde - Grundlangen. Z. Mitteilungen. 1992;82:39-4S.
Gross U, Brandes J, Strunz V, et al. The ultrastructure of the interface between a glass ceramic and bone. J Biomed Mater Res. 1981;1S(3):291-30S. doi: 10.1002/jbm.8201S0302
Bauer IW, Li SP, Han YC, et al. Internalization of hydroxyapatite nanoparticles in liver cancer cells. J Mater Sci Mater Med. 2008;19(3):1091-109S. doi: 10.1007/s108S6-007-3124-4
Hulbert SF, Cooke FW, Klawitter JJ, et al. Attachment of prostheses to the musculoskeletal system by tissue ingrowth and mechanical interlocking. J Biomed Mater Res. 1973;7(3):1-23. doi: 10.1002/jbm.820070303
Greenspan DC, Hench LL. Chemical and mechanical behavior of bioglass-coated alumina. J Biomed Mater Res. 1976;10(4):S03-S09. doi: 10.1002/ jbm.82010040S
Gross KA, Ray N, R0kkum M. The contribution of coating microstructure to degradation and particle release in hydroxyapatite coated prostheses. J Biomed Mater Res. 2002;63(2):106-114. doi: 10.1002/jbm.10090
Saravanapavan P, Jones JR, Pryce RS, Hench LL. Bioactivity of gel-glass powders in the CaO-SiO2 system: a comparison with ternary (CaO-P2OS-SiO2) and quaternary glasses (SiO2-CaO-P2OS-Na2O). J Biomed Mater Res A. 2003;66(1):110-119. doi: 10.1002/jbm.a.10S32
Plenk H Jr. Prosthesis-bone interface. J Biomed Mater Res. 1998;43(4):3S0-3SS. doi: 10.1002/(sici)1097-4636(199824)43:4<3S0::aid-jbm2-3.0.co;2-s
Anselme K, Noël B, Hardouin P. Human osteoblast adhesion on titanium alloy, stainless steel, glass and plastic substrates with same surface topography. J Mater Sci Mater Med. 1999;10(12):81S-819. doi: 10.1023/a:1008992109670
Keller JC, Collins JG, Niederauer GG, McGee TD. In vitro attachment of osteoblast-like cells to osteoceramic materials. Dent Mater. 1997;13(1):62-8. doi: 10.1016/s0109-S641(97)80010-3
Zinger O, Anselme K, Denzer A, et al. Time-dependent morphology and adhesion of osteoblastic cells on titanium model surfaces featuring scale-resolved topography. Biomaterials. 2004;2S(14):269S-711. doi: 10.1016/j.biomaterials.2003.09.111
Thomas KA, Cook SD, Haddad RJ Jr, et al. Biologic response to hydroxylapatite-coated titanium hips. A preliminary study in dogs. J Arthroplasty. 1989;4(1):43-S3. doi: 10.1016/s0883-S403(89)800S3-1
Jansen JA, van de Waerden JP, Wolke JG, de Groot K. Histologic evaluation of the osseous adaptation to titanium and hydroxyapatite-coated titanium implants. J Biomed Mater Res. 1991;2S(8):973-989. doi: 10.1002/jbm.8202S080S
Dhert WJ, Klein CP, Jansen JA, et al. A histological and histomorphometrical investigation of fluorapatite, magnesiumwhitlockite, and hydroxylapatite plasma-sprayed coatings in goats. J Biomed Mater Res. 1993;27(1):127-38. doi: 10.1002/jbm.820270116
S0balle K, Hansen ES, Brockstedt-Rasmussen H, et al. Gap healing enhanced by hydroxyapatite coating in dogs. Clin Orthop Relat Res. 1991;(272):300-307.
Stephenson PK, Freeman MA, Revell PA, et al. The effect of hydroxyapatite coating on ingrowth of bone into cavities in an implant. J Arthroplasty. 1991;6(1):S1-S8. doi: 10.1016/s0883-S403(06)801S7-9
Oliveira AS, Silva JC, Figueiredo L, et al. High-performance bilayer composites for the replacement of osteochondral defects. Biomater Sci. 2022;10(20):5856-5875. doi: 10.1039/d2bm00716a
Zaed I, Cardia A, Stefini R. From Reparative Surgery to Regenerative Surgery: State of the Art of Porous Hydroxyapatite in Cranioplasty. Int J Mol Sci. 2022;23(10):S434. doi: 10.3390/ijms2310S434
Sarkar SK, Lee BT. Hard tissue regeneration using bone substitutes: an update on innovations in materials. Korean J Intern Med. 201S;30(3):279-293. doi: 10.3904/kjim.201S.30.3.279
Nakamura T. Biomaterial osteoinduction. J Orthop Sci. 2007;12(2):111-112. doi: 10.1007/s00776-007-1109-2
Dorozhkin SV. Calcium orthophosphate deposits: Preparation, properties and biomedical applications. Mater Sci Eng C Mater Biol Appl. 201S;SS:272-326. doi: 10.1016/j.msec.201S.0S.033
LeGeros RZ. Calcium phosphate-based osteoinductive materials. Chem Rev. 2008;108(11):4742-S3. doi: 10.1021/cr800427g
Popkov AV, Popkov DA. Bioactive implants in traumatology and orthopaedics. Irkutsk: NTsRVKH SO RAMS; 2012:438. (In Russ.)
Popkov AV, Popkov DA, Borzunov DYu. Directed osteoinduction for bone fibrous dysplasia. Genij Ortopedii. 2013;(1):81-86. (In Russ.)
Popkov A, Kononovich N, Gorbach E, Popkov D. Osteointegration technology in long bone defect reconstruction: experimental study. Acta Bioeng Biomech. 2020;22(4):8S-91.
Agadzhanyan VV, Tverdokhlebov SI, Bolbasov EN, Ignatov VP, Shesterikov EV. Osteoinductive coatings based on calcium phosphates and prospects for their usage in polytrauma treatment. Polytrauma. 2011;(3):S-13. (In Russ.)
Aronov AM, Bolbasov EN, Guzeev VV. Biocomposites based on a copolymer of tetrafluoroethylene with vinylidene fluoride filled with hydroxyapatite and the possibility of their use as a coating for intramedullary implants. Med Technol. 2010;(3):S-13. (In Russ.)
Aronov AM, Pichugin VF, Tverdokhlebov SI. Methodological bases for the development and organization of the production of medical products. Tomsk: Veter; 2007:334. (In Russ.)
Yannas IV. What criteria should be used for designing artificial skin replacements and how well do the current grafting materials meet these criteria? J Trauma. 1984;24(9 Suppl):S29-39.
Reddi AH. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotechnol. 1998;16(3):247-2S2. doi: 10.1038/ nbt0398-247
Khoninov BV, Sergunin ON, Skoroglyadov PA. Biodegradable materials application in traumatology and orthopedics (Review). Bulletin of the Russian State Medical University. 2014;(1):20-24. (In Russ.)
Rokkanen PU, Böstman O, Hirvensalo E, et al. Bioabsorbable fixation in orthopaedic surgery and traumatology. Biomaterials. 2000;21(24):2607-2613. doi: 10.1016/s0142-9612(00)00128-9
Ruedi T. AO Principles of Fracture Management: Vol. 1: Principles. Buckley RE (Ed., Contrib.), Moran CG (Ed., Contrib.). 2013; Berlin, Wassa Media. 1:1-8,32-46,212-226.
Khoninov BV, Sergunin ON, Skoroglyadov PA. Clinical efficacy analysis of biodegradable implants application on the surgical treatment of hallux valgus. Bulletin of the Russian State Medical University. 201S;(3):20-24. (In Russ.)
Nishizuka T, Kurahashi T, Hara T, et al. Novel intramedullary-fixation technique for long bone fragility fractures using bioresorbable materials. PLoS One. 2014;9(8):e104603. doi: 10.1371/journal.pone.0104603
Gaiarsa GP, Dos Reis PR, Mattar R Jr, et al. Comparative study between osteosynthesis in conventional and bioabsorbable implants in ankle fractures. Acta Ortop Bras. 201S;23(S):263-267. doi: 10.1590/1413-785220152305121124
Zhang J, Ebraheim N, Lausé GE, et al. A comparison of absorbable screws and metallic plates in treating calcaneal fractures: a prospective randomized trial. J Trauma Acute Care Surg. 2012;72(2):E106-10. doi: 10.1097/ta.0b013e3182231811
Agadzhanyan VV, Pronskikh AA, Demina VA, et al. Biodegradable implants in orthopedics and traumatology. Our first experience. Polytrauma. 2016;(4):8S-93.
Zamora R, Jackson A, Seligson D. Correct techniques for the use of bioabsorbable implants in orthopaedic trauma. Current Orthopaedic Practice. 2016;27(4): 469-73. doi: 10.1097/Bœ.0000000000000378
Castaño O, Sachot N, Xuriguera E, et al. Angiogenesis in bone regeneration: tailored calcium release in hybrid fibrous scaffolds. ACS Appl Mater Interfaces. 2014;6(10):7S12-22. doi: 10.1021/amS0088Sv
Kulkarni RK, Pani KC, Neuman C, Leonard F. Polylactic acid for surgical implants. Arch Surg. 1966;93(S):839-43. doi: 10.1001/ archsurg.1966.013300S0143023
Kulkarni RK, Moore EG, Hegyeli AF, Leonard F. Biodegradable poly(lactic acid) polymers. J Biomed Mater Res. 1971;S(3):169-81. doi: 10.1002/ jbm.8200S030S
Waris E, Konttinen YT, Ashammakhi N, et al. Bioabsorbable fixation devices in trauma and bone surgery: current clinical standing. Expert Rev Med Devices. 2004;1(2):229-40. doi: 10.1S86/17434440.1.2.229
Vainionpää S, Rokkanen P, Törmälä P. Surgical applications of biodegradable polymers in human tissues. Progress Polymer Science. 1989;14(S):679-716. doi: 10.1016/0079-6700(89)90013-0
Speer KP, Warren RF. Arthroscopic shoulder stabilization. A role for biodegradable materials. Clin Orthop Relat Res. 1993;(291):67-74.
Merolli A, Nicolais L, Ambrosio L, Santin M. A degradable soybean-based biomaterial used effectively as a bone filler in vivo in a rabbit. Biomed Mater. 2010;S(1):1S008. doi: 10.1088/1748-6041/S/1/01S008
Isyar M, Yilmaz I, Nusran G, et al. Safety of bioabsorbable implants in vitro. BMC Surg. 201S;1S:127. doi: 10.1186/s12893-01S-0111-4
Yakimov LA, Slinyakov LYu, Bobrov DS, et al. Biodegradable implants. Formation and development. Advantages and disadvantages. (review of literature). Department of Traumatology and Orthopedics. 2017;1:47-52. (In Russ.)
Andriano KP, Pohjonen T, Törmälä P. Processing and characterization of absorbable polylactide polymers for use in surgical implants. J Appl Biomater. 1994;5(2):133-140. doi: 10.1002/jab.770050206
Eglin D, Alini M. Degradable polymeric materials for osteosynthesis: tutorial. Eur Cell Mater. 2008;16:80-91. doi: 10.22203/ecm.v016a09
Kontakis GM, Pagkalos JE, Tosounidis TI, et al. Bioabsorbable materials in orthopaedics. Acta Orthop Belg. 2007;73(2):159-169.
Pina S, Ferreira JMF. Bioresorbable Plates and Screws for Clinical Applications: A Review. J Healthcare Engineering. 2012;3(2):243-260. doi: 10.1260/2040-2295.3.2.243
Sheikh Z, Najeeb S, Khurshid Z, et al. Biodegradable Materials for Bone Repair and Tissue Engineering Applications. Materials (Basel). 2015;8(9):5744-5794. doi: 10.3390/ma8095273
Landes CA, Ballon A, Roth C. Maxillary and mandibular osteosyntheses with PLGA and P(L/DL)LA implants: a 5-year inpatient biocompatibility and degradation experience. Plast Reconstr Surg. 2006;117(7):2347-2360. doi: 10.1097/01.prs.0000218787.49887.73
Shilova AN, Ilarionov SA. Biopolymers based on lactide. Bulletin of Perm University. 2015;1(17):86-92. (In Russ.)
Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials. 2000;21(24):2529-2543. doi: 10.1016/s0142-9612(00)00121-6
Strycker ML. Biodegradable internal fixation. J Foot Ankle Surg.. 1995;34(1):82-88. doi: 10.1016/S1067-2516(09)80107-5
Ciccone WJ 2nd, Motz C, Bentley C, Tasto JP. Bioabsorbable implants in orthopaedics: new developments and clinical applications. J Am Acad Orthop Surg. 2001;9(5):280-188. doi: 10.5435/00124635-200109000-00001
Daniels AU, Chang MK, Andriano KP. Mechanical properties of biodegradable polymers and composites proposed for internal fixation of bone. J Appl Biomater. 1990;1(1):57-78. doi: 10.1002/jab.770010109
Young A, Maia R, Moraga C, et al. Latarjet-Bristow Procedure Performed With Bioabsorbable Screws: Computed Tomography Evidence of Healing. Techniques in Shoulder and Elbow Surgery. 2010;11(3):85-89. doi: 10.1097/BTE.0b013e3181edf171
Washington MA, Swiner DJ, Bell KR, et al. The impact of monomer sequence and stereochemistry on the swelling and erosion of biodegradable poly(lactic-co-glycolic acid) matrices. Biomaterials. 2017;117:66-76. doi: 10.1016/j.biomaterials.2016.11.037
Välimaa T, Laaksovirta S. Degradation behaviour of self-reinforced 80L/20G PLGA devices in vitro. Biomaterials. 2004;25(7-8):1225-32. doi: 10.1016/j.biomaterials.2003.08.072
Golubev VG, Starostenkov AN. Bioabsorbable screws as a new facility for calcaneal fractures treatment. Department of Traumatology and Orthopedics. 2017;(2):25-30. (In Russ.)
Böstman O, Hirvensalo E, Mäkinen J, Rokkanen P. Foreign-body reactions to fracture fixation implants of biodegradable synthetic polymers. J Bone Joint Surg Br. 1990;72(4):592-596. doi: 10.1302/0301-620X.72B4.2199452
Böstman OM. Metallic or absorbable fracture fixation devices. A cost minimization analysis. Clin Orthop Relat Res. 1996;(329):233-9.
Golubev VG, Starostenkov AN. Operative technique features in application of bioabsorbable implants for limb fractures treatment. Surgical practice. 2017;(2):5-13. (In Russ.)
Golubev VG, Zelenyak KB, Starostenkov AN. Bioabsorbable implants in treatment Of ankle fractures (comparative study). Department of Traumatology and Orthopedics. 2018;(2): 66-73. (In Russ.) doi: 10.17238/issn2226-2016.2018.2.66-73
Bruder SP, Kraus KH, Goldberg VM, Kadiyala S. The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am. 1998;80(7):985-96. doi: 10.2106/00004623-199807000-00007
Ivanov SY, Panasyuk AF, Panin AM et al. Experience in the use of biocomposite osteoplastic materials. Nizhny Novgorod Medical Journal. Supplement to NMG (dentistry 2003). 2003;(2):244-50. (In Russ.)
Kuz'minykh IA. Clinical experience in osteoplastic material Allomatrix-implant and fibrin rich platelets use in surgical treatment of jaw radicular cysts. Stomatologiia (Mosk). 2009;88(1):51-53. (In Russ.)
Ivanov SY, Kuznetsov RK, Chailakhyan RK. Prospects for the use of Biomatrix and Allomatrix-implant materials in combination with bone marrow osteogenic progenitor cells in dentistry. Clinical implantology and dentistry. 2000;(3-4):17-18. (In Russ.)
Grudyanov AI, Panasuk AF, Larionov EV, Biakova SF. The use of biocomposite osteoplastic material "Allomatrix-implant" in the surgical treatment of inflammatory periodontal diseases. Periodontology. 2003;4(29):39-43. (In Russ.)
Litvinov SD, Rakhimov RI. [Tooth bud fixation by the material LitAr]. Stomatologiia (Mosk). 2005;84(2):62-65. (In Russ.)
Asnina SA, Agapov VS, Savchenko ZI, Ignatiev EV. The use of biocomposite material "Osteomatrix" for the prevention of complications in the removal of impacted third molars. Institute of Dentistry. 2004;(1):46-49. (In Russ.)
Chekmazov IA, Riabov AL, Skalozub OI, Lapin RV. [Biocomposite nanostructured materials for the bone defects filling by osteomyelitis]. Khirurgiia (Mosk). 2013;(8):56-8. (In Russ.)
Protsenko AI, Gazhev AKh, Gordeev GG, Zheltikov DI. [The use of hydroxyapatite substance for the ostheosynthesis after comminuted thigh fractures]. Khirurgiia (Mosk). 2012;(1):10-4. (In Russ.)
Roberts SJ, Geris L, Kerckhofs G, et al. The combined bone forming capacity of human periosteal derived cells and calcium phosphates. Biomaterials. 2011;32(19):4393-4405. doi: 10.1016/j.biomaterials.2011.02.047
Furukawa T, Matsusue Y, Yasunaga T, et al. Bone bonding ability of a new biodegradable composite for internal fixation of bone fractures. Clin Orthop Relat Res. 2000;(379):247-58. doi: 10.1097/00003086-200010000-00030
Shikinami Y, Matsusue Y, Nakamura T. The complete process of bioresorption and bone replacement using devices made of forged composites of raw hydroxyapatite particles/poly l-lactide (F-u-HA/PLLA). Biomaterials. 2005;26(27):5542-51. doi: 10.1016/j.biomaterials.2005.02.016
Popkov AV, Stogov MV, Gorbach EN, et al. Hydrolysis of Bone-Replacing Materials Based on Polylactic Acid and Containing Hydroxyapatite in an In Vitro Experiment. Bull Exp Biol Med. 2022;174(1):99-103. doi: 10.1007/s10517-022-05656-3
Popkov AV, Popkov DA, Kononovich NA et al. Bioactive implants in the treatment of long bone nonunion and defects. Tomsk: Publishing House of Tomsk Polytechnic University; 2021:312.

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