Biochemistry of synovia proteoglycans in the dynamics of osteoarthrosis development

The content of glycosaminoglycans (GAG) and the complexes of proteoglycans (PG) were determined analytically in synovia of patients with osteoarthrosis of different stages by the method of electrophoresis in agarose gel. The amount of GAG in synovia increases at early stages of the disease, and at the late ones it decreases, thereby reflecting the dynamics of changes in articulate cartilage. The amount of GAG, their qualitative composition and PG structural aggregatbility can serve as a diagnostic test for risk of osteoarthrosis occurrence and its development dynamics.