Diagnosis and therapy of non-hodgkin's lymphomas (lecture). Part 1

Lymphoproliferative neoplasms are a huge group of diseases whose tumor substrate is a mature or immature altered (pathological) cell represented by a particular clone of lymphoid cells. Lymphomas belong to malignant tumor diseases with its own biological, morphological, clinical features, different response to treatment, prognosis and survival of patients. In this part of lecture are detailed modern diagnostic methods, with emphasis on histological and immunohistochemical studies of bone-marrow biopsy, lymph node, tumor mass, immunophenotyping of bone marrow and peripheral blood cells by flow cytometry, cytogenetic and molecular genetic methods of investigation, as well as PET-CT. Prognostic scales and staging in patients with diffuse B-cell large cell lymphoma, mantle cell lymphoma, and follicular lymphoma are presented in detail. The methods of evaluating the response to ongoing antitumor treatment are described in detail. The lecture is of particular interest to hematologists, oncologists, therapists, pediatricians, advanced training, as well as clinical residents and medical students.