Дополнительные диагностические возможности в практике ПАП-теста методом жидкостной цитологии

Дополнительные диагностические возможности в практике ПАП-теста методом жидкостной цитологии

Автор: Аксаментов Артем Константинович, Мельникова Надежда Васильевна, Колышкина Надежда Александровна, Кучерова Ольга Николаевна, Баклаушев Владимир Павлович

Журнал: Клиническая практика @clinpractice

Рубрика: Обзоры

Статья в выпуске: 1 т.12, 2021 года.

Бесплатный доступ

Роль проонкогенных штаммов вируса папилломы человека в развитии рака шейки матки не вызывает сомнений. В настоящее время в программах скрининга рака шейки матки применяется стратегия котестирования, включающая цитологическое и ВПЧ-исследования, которые могут быть осуществлены одномоментно при помощи инновационного метода - жидкостной цитологии (ЖЦ). Новейшая технология позволяет проводить дополнительные диагностические генетические исследования, благодаря которым возможна более эффективная сортировка пациентов с целью оптимизации объема диагностических и лечебных мероприятий. В статье изучена эффективность диагностических тестов на основе оценки экспрессии микроРНК и мРНК, а также тестов на основе анализа метилирования ДНК по материалу ЖЦ. Внедрение в клиническую практику исследований новых молекулярно-генетических предикторов развития рака шейки матки расширяет возможности скрининговых программ, применяемых в настоящее время.

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Пап-тест, скрининг, рак шейки матки, микрорнк, мрнк, жидкостная цитология, метилирование днк

Короткий адрес: https://sciup.org/143175842

IDR: 143175842   |   DOI: 10.17816/clinpract64982

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