Effect of acidic folici treatment on patients with henoch-scholein purpura with hereditary disruption metabolism of homocysteine

The effect of mutations in genes encoding enzymes of the folate cycle, on homocysteine metabolism in hemorrhagic vasculitis (HV) was investigated. It is shown that the most pronounced increase in homocysteine levels in the blood was in patients with genetic abnormalities of the two enzymes at the same time - methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR Ile22Met). Hypercoagulable changes in the hemostatic system in these patients corrected by not only the standard therapy, but also the appointment of folic acid, which is eliminated due to hyperhomocysteinemia. Maximum reduction of homocysteine in the blood relative to baseline when taking folic acid were in patients who have isolated a mutation MTHFR C677T. Folic acid not only helps to reduce laboratory changes in these patients with HV, but also has a positive effect on the course of the disease. Thus, in the examination of patients with HV program appropriate to include the definition of the level of homocysteine in the blood and the presence of mutations in MTHFR C677T and MTRR Ile22Met. In identifying these mutations should be the appointment of folic acid.