Formation of the system of anti-stressor reactions as a non-specific basis for health and longevity

The proposed editorial article touches upon aspects of fundamental medicine associated with the discovery of systems of nonspecific adaptation reactions in the organism as a whole. It is shown that the key law of the organism's response to the actions of the external and internal environment consists in the dependence between the reaction quality and the quantity (measure, intensity) of an acting factor. Revealed is the historical sequence of events in the development of the general adaptation reaction theory, beginning with the creation of the theoretical basis of pathology, i.e. description of the adaptation syndrome of stress reaction by Hans Selye, up to the intimate-ly associated and logically continued studies and discovery of anti-stress- type reactions, namely, the reactions of training and activation, undertaken by Lyubov Garkavi, Maria Ukolova and Elena Kvakina. The characterization of archetypes of previously unknown, independent separate symptom complexes is given herein. The philosophy of adaptation discrete responses provided by the organism to different actions includes a higher stage of research pro-gress, when it would be possible to understand the unique natural ability of periodic repetition of the adaptation reactions tetrad in a very wide range of action intensities.