Фундаментальные и клинические аспекты заболеваний щитовидной железы и новые подходы для их лечения (обзор литературы)

Фундаментальные и клинические аспекты заболеваний щитовидной железы и новые подходы для их лечения (обзор литературы)

Автор: Фокина Е.А., Шпаков А.О.

Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk

Рубрика: Клинические исследования

Статья в выпуске: 3 т.37, 2022 года.

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Распространенность заболеваний щитовидной железы (ЩЖ), в том числе аутоиммунного гипертиреоза (болезни Грейвса), аутоиммунного тиреоидита, различных форм тиреоидного рака, с каждым годом возрастает, в то время как эффективность их лечения по-прежнему остается низкой и ограничивается в основном заместительной терапией тиреоидными гормонами и хирургическими и радиоизотопными методами. В настоящем обзоре представлено современное состояние проблемы фармакологической коррекции заболеваний ЩЖ, рассмотрены новые подходы, направленные на регуляцию функциональной активности компонентов системы синтеза тиреоидных гормонов в фолликулярных клетках ЩЖ, включая его начальный, сенсорный, компонент - рецептор тиреотропного гормона. Среди препаратов, которые разрабатываются в настоящее время, необходимо выделить аллостерические регуляторы рецептора тиреотропного гормона, специфичные к нему антитела, а также селективные агонисты β-изоформы рецепторов тиреоидных гормонов.

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Щитовидная железа, рецептор тиреотропного гормона, тиреоидные гормоны, фармакотерапия, антитиреоидные препараты

Короткий адрес: https://sciup.org/149141439

IDR: 149141439   |   DOI: 10.29001/2073-8552-2022-37-3-90-97

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