Histostructure of internal organs of white rats in case of glyphosate poisoning during treatment with antitoxic agents

Glyphosate (N-(phosphonomethyl)-glycine) is a systemic herbicide of non-selective action for treatment of vegetative plants. In Russia, 40 thousand tons of glyphosate-based herbicides are used and 19 million hectares of crop areas are treated. The herbicide suppresses the synthesis of aromatic amino acids by inhibiting the enzyme - 5-enolopyruvil -shikimate-3-phosphate synthetase. However, in addition to glyphosate salts, commercial glyphosate formulations contain additives (known as adjuvants) such as surfactants, which vary in nature and concentration. Surfactants such as polyethoxylated tallow amine (POEA) are added to glyphosate to wet the leaves and penetrate the plant cuticle. Surfactants in glyphosate can increase the relative acute toxicity. Foreign researchers have shown that glyphosate has a toxic effect on the liver and kidneys, causes oxidative stress, reduces the content of vitamin D in the body, which ultimately leads to fibrotic replacement and tissue death, dysfunction of cell membranes and ischemia. The aim of the study was to evaluate the effect of the herbicide glyphosate at a dose of 5 MPC on the internal organs of white rats against the background of treatment with antitoxic agents. The results of the analysis showed that poisoning of white rats with glyphosate from the herbicide group at a level of 5 MPC had a significant effect on their internal organs. In experimental animals, hemocirculation and hemorheology were impaired. Necrobiotic changes were observed, in places with signs of an inflammatory cellular reaction, interstitial edemas and desquamation of the tubular epithelium. Based on the data obtained, it can be concluded that of the studied antitoxic agents in poisoning with this pesticide, xymedon-S had the most positive effect on the condition of the internal organs, the experimental sample based on tetraazatricyclo compound (TA) was less effective, and sodium sulfide showed virtually no therapeutic effect.