Immunophenotypic characteristics of the uortin-like variant of papillary cancer of the thyroid

Warthin-like variant of papillary thyroid carcinoma (WL-PTC) is one of the rarest histologic variants of papillary thyroid cancer, which remains poorly studied.The purpose of the study: the detection of pathomorphological and prognosti features of WL-PTC (immunohistochemical aspect). Materials and methods: Of 2380 cases of operated papillary thyroid cancer, 34 patients were diagnosed with WL-PTC (1.43%); women - 32, men - 2; the average age was 45 years. The obtained material was studied by light microscopy and immunohistochemistry (antibodies to CK9, CD15, CD138, TG). Results: in 20 cases positive reaction was observed with antibodies on CD15 (96.2 ± 0.1%); in 14 cases out of 34 (41.2%) it was found moderate labeling on CD138 (48.3 ± 0.1%). In all cases (n = 34), staining on TG was revealed: in patients without metastases in regional lymph nodes - 78.0 ± 0.3%, and in patients with metastases - 89.9 ± 0.1%. Conclusion: the data of clinico-morphological and immunohistochemical analysis (on CD19, CD15, CD138, TG) of the WL-PTC may be useful for a prognosis for this type of cancer.