A study of the efficacy of Cervikon-DIM medication in patients with grade 1-2 cervical intraepithelial neoplasia

Purpose of the study: To evaluate effectiveness of suppository medication Cervikon-DIM in patients with cervical CIN 1-2. Materials and methods: 65 patients with grade 1-2 CIN were included and randomized into two groups. The patients in the first experimental group received 200 mg DIM intravaginally per day. Patients in the second group received placebo. Efficacy was assessed after three months of therapy for a complete or partial regression of cervical lesions according to histological and colposcopic examination. Results: Based on histology results, statistically significant difference in efficacy between intravaginal application of the study medication (200 mg DIM per day) and placebo was demonstrated at 3 months of therapy (93,7% и 37,5%, р=0,0069). There was also statistically significant difference between experimental group and placebo according to colposcopy results (78,1% и 51,5%; p=0,023). Conclusions: Cervikon-DIM medication shows promising effectiveness in the treatment of CIN 1-2 at 3 months therapy.