The change in blood serum biochemical parameters for leg proximal third lengthening by transosseous osteosynthesis method according to Ilizarov

Purpose. To analyze the change in blood serum biochemical parameters in patients who underwent leg proximal third lengthening in order to increase their height, depending on the amount of lengthening. Materials and Methods. Blood serum studied biochemically in 45 patients who underwent leg proximal third lengthening in order to increase their height. The concentration of total protein, albumin, lactate was determined in blood serum, as well as creatine kinase (CK) activity. All the patients treated divided into three subgroups depending on the amount of lengthening. On the average the amount of lengthening was 10.9±2.83 % of the initial length of segment in the first subgroup, in the second one - 17.5±1.49 %, and in the third - 23.2±2.48 %. Results. The level of total protein established to increase slightly at the stage of distraction in all the subgroups. Creatine phosphokinase (CPK) activity increased significantly at the stage of distraction in all the patients examined, with the highest values in the third subgroup patients. Lactate level in blood serum significantly increased statistically as well in the third subgroup patients in the same period. Conclusion. The process of leg bone lengthening by more than 20 % of initial length leads to more significant change in organism’s systemic and local reactions comparing with lower amounts of lengthening.