Efficacy of pharmacotherapy of affective disorders comorbid with personality disorder

The present study investigates the effectiveness of pharmacotherapy in the case of comorbidity of affective and personality disorders. The total group of patients with a current depressive episode was divided into main subgroup (n=60) - with the presence of comorbid personality disorders and subgroup of comparison (n=60) - without comorbid personality disorders. As psychometric instruments scales SIGH-SAD, CGI-S, CGI-I and UKU were used. The presence of a comorbid personality disorder determined the greater severity of the current depressive episode, a slower reduction of the severity of the current depressive episode during therapy, the need for combination therapy and greater severity of side effects.