Evolution of approaches in liver tumor surgery

Purpose: To review current trends in liver surgery, accompanied by our own data. Methods. An analysis of the long-term results of treatment of patients after liver resection for colorectal cancer metastases is presented, depending on the width of indentation from the tumor node, the type of resection performed and the period of surgical intervention. The analysis was supplemented by a review of the modern literature. Results. The overall median follow-up in the group of patients with resections for colorectal cancer metastases to the liver was 80 months with 95% confidence interval [9.7;150.3]. Comparison of overall survival of patients with marginal margin up to 1 mm and greater than 1 mm showed no statistically significant difference (p=0.686). Three-year overall survival of patients with tumor margin indentation up to 1 mm was 66.5±13.9%, and 70.4±9.1% for patients with tumor margin indentation greater than 1 mm. Comparison of overall survival of the 2013-2015, 2016-2018, and 2019-2023 follow-up periods was not statistically significant (p=0.087). Comparison between the 2013-2015 and 2016-2023 periods was statistically significant (p=0.038). The three-year survival rate of patients of the 2013-2015 period was 37.5±17.1%, the 2013-2016 period was 82.5±8.0%, and the 2019-2023 period was 70.6±20.8%. The overall survival of patients with anatomic and atypical liver resection was not statistically significant (p=0.965). The three-year survival rate of patients with atypical resections was 67.0±11.6% and that of patients with anatomic resections was 76.9±9.3%.