К вопросу о нейротропности и нейроинвазивности коронавирусов

Автор: Войтенков Владислав Борисович, Екушева Евгения Викторовна

Журнал: Клиническая практика @clinpractice

Статья в выпуске: 2 т.11, 2020 года.

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В настоящий момент развития ситуации с инфекцией COVID-19 можно делать предварительные выводы относительно непосредственных и отдаленных последствий этого заболевания. В обзоре литературных данных мы предполагаем, что для вируса SARS-CoV-2, как и для ряда других вирусов семейства Coronaviridae, характерны нейротропность и нейроинвазивность с интраназальным путем доступа, который считается наиболее опасным с точки зрения дальнейшего развития неврологических осложнений с поражением клеток дыхательного центра. Кроме того, лекарственные средства для интраназального применения, обладающие местными иммуномодулирующими и противовирусными свойствами, могут рассматриваться в качестве возможных методов профилактики и терапии лиц, контактирующих с пациентами, инфицированных COVID-19, что требует дальнейшего углубленного изучения. Возможным объяснением развития дыхательной недостаточности у ряда пациентов является угнетение дыхательного центра, что также нуждается в дальнейшем подробном изучении с проведением рандомизированных экспериментальных, клинических и патоморфологических исследований.

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Коронавирусы, интраназальный путь, неврологические осложнения, сoronaviruses

Короткий адрес: https://sciup.org/143172656

IDR: 143172656 | DOI: 10.17816/clinpract34890

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