Clinical case of Waldenstroem’s macroglobulinemia, with hemolytic anemia debut

The diagnosis of Waldenstrom's macroglobulinemia is not simple. The variety of clinical and morphological manifestations occurring with monoclonal macroglobulinemia is so great that the diagnosis of the disease may have certain difficulties, especially in the early stages. Of the primary clinical manifestations caused by the circulation of macroglobulin in the blood, an increase in viscosity and hemorrhagic syndrome can be called. The hemolytic component occurs only in 5% of cases and is still insufficiently studied. A clinical case of Waldenström's macroglobulinemia is presented, which debuted with severe hemolytic anemia that is not amenable to therapy, and the underlying disease proceeded with an atypical clinical picture and laboratory data. Only an in-depth additional study made it possible to establish the correct diagnosis and achieve an improvement in all indicators based on the prescribed pathogenetic treatment.