Treatment of wounds in the neuropathic form of diabetic foot syndrome using platelet-rich autoplasma: problems and prospects

Introduction. The neuropathic form of diabetic foot syndrome develops as a result of hyperglycemia and neuropathy, which further leads to a violation of reparative processes. The standard amount of therapy, including surgical treatment of the wound, systemic antibacterial therapy, and limb unloading, is often insufficient to stimulate healing. Platelet–rich autoplasma (PRP) containing growth factors is a promising treatment method that accelerates tissue repair. This review examines the effectiveness of PRP in stimulating the healing of chronic wounds, including wounds with neuropathic form of diabetic foot syndrome. The purpose of this study is to review the available literature from domestic and foreign authors and to systematize the data on the mechanism of action, clinical efficacy, and optimal protocols for using platelet–rich autoplasma in the treatment of wounds in NFSDS. Materials and methods. Analysis of available literary data of foreign and domestic authors, scientific databases e–library, PubMed, PMC. Results. The analysis of literature data proved the role of PRP in accelerating wound healing in neuropathic form of diabetic foot syndrome by stimulating angiogenesis, collagen synthesis, and reducing the risk of amputations and infection recurrence. The technique does not replace the standard treatment, but increases its effectiveness. Conclusion. The use of platelet–rich autoplasma makes it possible to increase the effectiveness of treatment of chronic wounds, including wounds with neuropathic form of diabetic foot syndrome by activating reparative processes. This method can be considered as a component of personalized therapy.