Лучевая терапия в комплексном лечении герминативно-клеточных опухолей головного мозга у детей и подростков. Достижения и проблемы

Лучевая терапия в комплексном лечении герминативно-клеточных опухолей головного мозга у детей и подростков. Достижения и проблемы

Автор: Щербенко Олег Ильич

Журнал: Вестник Российского научного центра рентгенорадиологии Минздрава России @vestnik-rncrr

Рубрика: Обзоры, лекции

Статья в выпуске: 4 т.14, 2014 года.

Бесплатный доступ

Целью настоящего обзора является оценка современной роли лучевой терапии в лечении герминативно-клеточных опухолей (ГКО) у детей и возможных путей улучшения результатов терапии. Анализ имеющихся в системе Medline публикаций по проблеме лечения ГКО у детей за последние 25 лет позволил выделить следующие основные положения. Лучевая терапия была и остается ведущим, но, в то же время, дающим наиболее значимые отдаленные последствия, методом лечения ГКО головного мозга. Применение неоадъювантной химиотерапии позволяет снизить дозы лучевой терапии без ущерба для эффекта лечения. Снижение доз облучения здоровых тканей возможно также путем использования современных технических средств и приемов лучевой терапии. Высокая чувствительность «чистых» гермином к химиопрепаратам и лучевой терапии позволяет продолжить поиск, направленный на дальнейшее снижение дозировок обоих агентов. Программы лечения негерминомных опухолей нуждаются в совершенствовании за счет оптимизации объемов и доз облучения с целью повышения показателей безрецидивного течения и выживаемости при дальнейшем уменьшении частоты и выраженности отдаленных последствий лечения.

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Дети, герминативно-клеточные опухоли, лучевая терапия, химиотерапия

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IDR: 14955458

Список литературы Лучевая терапия в комплексном лечении герминативно-клеточных опухолей головного мозга у детей и подростков. Достижения и проблемы

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