Лучевая терапия в комплексном лечении герминативно-клеточных опухолей головного мозга у детей и подростков. Достижения и проблемы

Автор: Щербенко Олег Ильич

Журнал: Вестник Российского научного центра рентгенорадиологии Минздрава России @vestnik-rncrr

Статья в выпуске: 4 т.14, 2014 года.

Бесплатный доступ

Целью настоящего обзора является оценка современной роли лучевой терапии в лечении герминативно-клеточных опухолей (ГКО) у детей и возможных путей улучшения результатов терапии. Анализ имеющихся в системе Medline публикаций по проблеме лечения ГКО у детей за последние 25 лет позволил выделить следующие основные положения. Лучевая терапия была и остается ведущим, но, в то же время, дающим наиболее значимые отдаленные последствия, методом лечения ГКО головного мозга. Применение неоадъювантной химиотерапии позволяет снизить дозы лучевой терапии без ущерба для эффекта лечения. Снижение доз облучения здоровых тканей возможно также путем использования современных технических средств и приемов лучевой терапии. Высокая чувствительность «чистых» гермином к химиопрепаратам и лучевой терапии позволяет продолжить поиск, направленный на дальнейшее снижение дозировок обоих агентов. Программы лечения негерминомных опухолей нуждаются в совершенствовании за счет оптимизации объемов и доз облучения с целью повышения показателей безрецидивного течения и выживаемости при дальнейшем уменьшении частоты и выраженности отдаленных последствий лечения.

Еще

Дети, герминативно-клеточные опухоли, лучевая терапия, химиотерапия

Короткий адрес: https://sciup.org/14955458

IDR: 14955458

Список литературы Лучевая терапия в комплексном лечении герминативно-клеточных опухолей головного мозга у детей и подростков. Достижения и проблемы

Aizer A.A., Sethi R.V., Hedley-Whyte E.T., et al. Bifocal intracranial tumors of nongerminomatous germ cell etiology: diagnostic and therapeutic implications.//Neuro Oncol. 2013. V.15. N7. P.955-960.
Alapetite C., Brisse H., Patte C., et al. Pattern of relapse and outcome of non-metastatic germinoma patients treated with chemotherapy and limited field radiation: the SFOP experience.//Neuro Oncol. 2010. N12. P.1318-1325.
Allen J.C., Kim J.H., Packer R.J. Neoadjuvant chemotherapy for newly diagnosed germcell tumors of the central nervous system.//J Neurosurg. 1987. V67. N1. P.65-70.
Aoyama H. Radiation therapy for intracranial germ cell tumors.//Prog Neurol Surg. 2009. N23. P.96-105.
Aoyama H., Shirato H., Kakuto Y., et al. Pathologically-proven intracranial germinoma treated with radiation therapy.//Radiother Oncol. 1998. V.47. N2. P.201-205.
Aoyama H., Shirato H., Ikeda J., et al. Induction chemotherapy followed by low-dose involved-field radiotherapy for intracranial germ cell tumors.//J Clin Oncol. 2002. V.20.N3. P.857-865.
Bamberg M., Kortmann R.D., Calaminus G., et al. Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89.//J Clin Oncol. 1999. V.17. N8. P.2585-2592.
Baranzelli M.C., Patte C., Bouffet E., et al. Nonmetastatic intracranial germinoma: the experience of the French Society of Pediatric Oncology.//Cancer. 1997. V80. N9. P.1792-1797.
Bouffet E., Baranzelli M.C., Patte C., et al. Combined treatment modality for intracranial germinomas: results of a multicentre SFOP experience. Société Française d'Oncologie Pédiatrique.//Br J Cancer. 1999. V.79. N7-8. P.1199-1204.
Calaminus G., Bamberg M., Jürgens H., at al. Impact of surgery, chemotherapy and irradiation on long term outcome of intracranial malignant non-germinomatous germ cell tumors: results of the German Cooperative Trial MAKEI 89.//Klin Pеdiatr. 2004. V.216.N3. P.141-149.
Calaminus G., Kortmann R., Worch J., et al. SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease.//Neuro Oncol. 2013. V. 157 P. 88-96.
Carlos Chung K.H., Owler B.K., at al. Paediatric germ cell tumours of the central nervous system: Results and experience from a tertiary-referral paediatric institution in Australia.//J Clin Neurosci. 2013. V.20. N4. P. 514-519.
Chen Y.W., Huang P.I., Hu Y.W., et al. Treatment strategies for initially disseminated intracranial germinomas: experiences at a single institute.//Childs Nerv Syst. 2012. V.28. N4. P.557-563.
Chen M.J., Santos Ada S., Sakuraba R.K., et al. Intensity-modulated and 3D-conformal radiotherapy for whole-ventricular irradiation as compared with conventional whole-brain irradiation in the management of localized central nervous system germ cell tumors.//Int J Radiat Oncol Biol Phys. 2010. V.76. N2. P.608-614.
Chen Y.W., Huang P.I., Ho D.M., at al. Change in treatment strategy for intracranial germinoma: long-term follow-up experience at a single institute.//Cancer. 2012. V.118. N10. P.2752-2762.
Chitapanarux I., Lorvidhaya V., Kamnerdsupaphon P., et al. CNS germ cell tumors: pattern of failure and effects of radiation volume.//J Med Assoc Thai. 2006. V.89. N4. P.415-421.
Cho J., Choi J.U., Kim D.S., Suh C.O. Low-dose craniospinal irradiation as a definitive treatment for intracranial germinoma.//Radiother Oncol. 2009. V.91. N1. P.75-79.
Dattoli M.J., Newall J.Radiation therapy for intracranial germinoma: the case for limited volume treatment.//Int J Radiat Oncol Biol Phys. 1990. V.19.N2. P.429-433.
Douglas J.G., Rockhill J.K., Olson J.M., et al. Cisplatin-based chemotherapy followed by focal, reduced-dose irradiation for pediatric primary central nervous system germinomas.//J Pediatr Hematol Oncol. 2006. V.28. N1. P.36-39.
Farng K.T., Chang K.P., Wong T.T., et al. Pediatric intracranial germinoma treated with chemotherapy alone.//Zhonghua Yi Xue Za Zhi (Taipei). 1999. V. 62. N12. P.859-866.
Friedman J.A., Lynch J.J., Buckner J.C., et al. Management of malignant pineal germ cell tumors with residual mature teratoma.//Neurosurgery. 2001. V. 48. N3. P.518-522.
Fujimaki T. Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.//J Child Neurol. 2009. V.24. N11. P. 39-45.
Haas-Kogan D.A., Missett B.T., Wara W.M., et al. Radiation therapy for intracranial germ cell tumors.//Int J Radiat Oncol Biol Phys. 2003. V.56. N2. P.511-518.
Haddock M.G., Schild S.E., Scheithauer B.W., Schomberg P.J. Radiation therapy for histologically confirmed primary central nervous system germinoma.//Int J Radiat Oncol Biol Phys. 1997. V.38. N5. P.915-923.
Halperin E.C., Constine L.S., Tarbell N.J., Can L.T. Pediatric Radiation Oncology. Raven Press.New York. Third Ed. 2006. 688 р.
Hardenbergh P.H., Golden J., Billet A., et al. Intracranial germinoma: the case for lower dose radiation therapy.//Int J Radiat Oncol Biol Phys. 1997. V.39. N2. P.419-426.
Hong J.Y., Kim G.W., Kim C.U., et al. Supine linac treatment versus tomotherapy in craniospinal irradiation: planning comparison and dosimetric evaluation.//Radiat Prot Dosimetry. 2011. V.146. N1-3. P.364-366.
Hong J., Wang X., Peng Y., et al. Clinical analysis of 45 patients with intracranial germinoma treated by radiotherapy.//Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013. V.38. N3. P.262-267.
Jaing T.H., Wang H.S., Hung I.J., et al. Intracranial germ cell tumors: a retrospective study of 44 children.//Pediatr Neurol. 2002. V.26. N5. P. 369-373.
Jensen A.W., Laack N.N., Buckner J.C., et al. Long-term follow-up of dose-adapted and reduced-field radiotherapy with or without chemotherapy for central nervous system germinoma.//Int J Radiat Oncol Biol Phys. 2010. V.77. N5. P. 1449-1456.
Jinguji S., Yoshimura J., Nishiyama K., et al. Factors affecting functional outcomes in longterm survivors of intracranial germinomas: a 20-year experience in a single institution.//J Neurosurg Pediatr. 2013. V.11. N4. P.454-463.
Kanamori M., Kumabe T., Saito R., et al. Optimal treatment strategy for intracranial germ cell tumors: a single institution analysis.//J Neurosurg Pediatr. 2009.V4. N6. P.506-514.
Kawabata Y., Takahashi J.A., Arakawa Y, et al. Long term outcomes in patients with intracranial germinomas: a single institution experience of irradiation with or without chemotherapy.//J Neurooncol. 2008. V.88. N2. P.161-167.
Kellie S.J., Boyce H., Dunkel I.J., et al. Intensive cisplatin and cyclophosphamide-based chemotherapy without radiotherapy for intracranial germinomas: failure of a primary chemotherapy approach.//Pediatr Blood Cancer. 2004. V.43. N2. P.126-133.
Khatua S., Dhall G., O'Neil S., et al. Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation.//Pediatr Blood Cancer. 2010. V.55. N1. P.42-46.
Kim J.W., Kim W.C., Cho J.H., et al. A multimodal approach including craniospinal irradiation improves the treatment outcome of high-risk intracranial nongerminomatous germ cell tumors.//Int J Radiat Oncol Biol Phys. 2012. V.84. N3. P.625-631.
Kortmann R.D. Current concepts and future strategies in the management of intracranial germinoma.//Expert Rev Anticancer Ther. 2014.V.14. N1. P.105-119.
Kumabe T., Kusaka Y., Jokura H., et al. Recurrence of intracranial germinoma initially treated with chemotherapy only.//No Shinkei Geka. 2002. V.30.N9. P.935-942.
Kumabe T., Jokura H., Tominaga T. Stereotactic radiosurgery followed by whole ventricular irradiation for primary intracranial germinoma of the pineal region.//Minim Invasive Neurosurg. 2005. V.48. N3. P.186-190.
Lafay-Cousin L., Millar B.A., Mabbott D., et al. Limited-field radiation for bifocal germinoma.//Int J Radiat Oncol Biol Phys. 2006. V.65. N2. P. 486-492.
Mabbott D.J., Monsalves E., Spiegler B.J., et al. Longitudinal evaluation of neurocognitive function aftertreatment for central nervous system germ cell tumors in childhood.//Cancer. 2011. V.117. N23. P.5402-5411.
MacDonald S.M., Trofimov A., Safai S., et al. Proton radiotherapy for pediatric central nervous system germ cell tumors: early clinical outcomes.//Int J Radiat Oncol Biol Phys. 2011. V.79. N1. P.121-129.
Maity A., Shu H.K., Janss A., et al. Craniospinal radiation in the treatment of biopsy-proven intracranial germinomas: twenty-five years' experience in a single center.//Int J Radiat Oncol Biol Phys. 2004. V.58. N4. P. 1165-1170.
Malone K., Croke J., Malone C., Malone S. Successful salvage using combined radiation and ABMT for patients with recurrent CNS NGGCT following failed initial transplant.//BMJ Case Rep. 2012 Jul 19;2012.
Matsutani M.; Japanese Pediatric Brain Tumor Study Group. Combined chemotherapy and radiation therapy for CNS germ cell tumors-the Japanese experience.//J Neurooncol. 2001. V.54. N3. P. 311-316.
Merchant T.E., Davis B.J., Sheldon J.M., Leibel S.A. Radiation therapy for relapsed CNS germinoma after primary chemotherapy.//J Clin Oncol. 1998. V.16. N1. P.204-209.
Merchant T.E., Sherwood S.H., Mulhern R.K., et al. CNS germinoma: disease control and long-term functional outcome for 12 children treated with craniospinal irradiation.//Int J Radiat Oncol Biol Phys. 2000. V.46.N5. P.1171-1176.
Nakamura H., Takeshima H., Makino K., et al. Recurrent intracranial germinoma outside the initial radiation field: a single-institution study.//Acta Oncol. 2006. V.45. N4. P.476-483.
Nishizaki T., Kajiwara K., Adachi N., et al. Detection of craniospinal dissemination of intracranial germ cell tumours based on serum and cerebrospinal fluid levels of tumour markers.//J Clin Neurosci. 2001. V.8. N1. P.27-30.
Nguyen Q.N., Chang E.L., Allen P.K., et al. Focal and craniospinal irradiation for patients with intracranial germinoma and patterns of failure.//Cancer. 2006. V.107. N9. P.2228-2236.
Odagiri K., Omura M., Hata M., et al. Treatment outcomes, growth height, and neuroendocrine functions in patients with intracranial germ cell tumors treated with chemoradiationtherapy.//Int J Radiat Oncol Biol Phys. 2012. V.84. N3. P.632-638.
Ogawa K., Shikama N., Toita T., et al. Long-term results of radiotherapy for intracranial germinoma: a multi-institutional retrospective review of 126 patients.//Int J Radiat Oncol Biol Phys. 2004. V. 58. N3. P.705-713.
Ogawa K., Yoshii Y., Shikama N., et al. Spinal recurrence from intracranial germinoma: risk factors and treatment outcome for spinal recurrence.//Int J Radiat Oncol Biol Phys. 2008. V.72. N5. P.1347-1354.
O'Neil S., Ji L., Buranahirun C., et al. Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation.//Pediatr Blood Cancer. 2011. V.57.N4. P.669-673.
Packer R.J., Cohen B.H., Cooney K. Intracranial germ cell tumors.//Oncologist. 2000. V.5. N4. P.312-320.
Paximadis P., Hallock A., Bhambhani K., et al.Patterns of failure in patients with primary intracranial germinoma treated with neoadjuvant chemotherapy and radiotherapy.//Pediatr Neurol. 2012. V.47. N3. P.162-166.
Purdy J.A. Dose to normal tissues outside the radiation therapy patient's treated volume: a review of different radiation therapy techniques.//Health Phys. 2008. V.95. N5. P.666-676.
Qi X.S., Stinauer M., Rogers B., et al. Potential for improved intelligence quotient using volumetric modulated arc therapy compared with conventional 3-dimensional conformal radiation for whole-ventricular radiation in children.//Int J Radiat Oncol Biol Phys. 2012. V.84. N5. P.1206-1211.
Raiyawa T., Khorprasert C., Lertbutsayanukul C., et al.Management of intracranial germ cell tumors at the King Chulalongkorn Memorial Hospital.//J Med Assoc Thai. 2012. V.95. N10. P.1327-1334.
Roberge D., Kun L.E., Freeman C.R. Intracranial germinoma: on whole-ventricular irradiation.//Pediatr Blood Cancer. 2005. V.44. N4. P.358-362.
Rogers S.J., Mosleh-Shirazi M.A., Saran F.H. Radiotherapy of localised intracranial germinoma: time to sever historical ties?//Lancet Oncol. 2005. V. 6. N7. P.509-519.
Shibamoto Y., Sasai K., Oya N., Hiraoka M. Intracranial germinoma: radiation therapy with tumor volume-based dose selection.//Radiology. 2001. V.218. N2. P.452-456.
Shikama N., Ogawa K., Tanaka S., et al. Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma: a multiinstitutional, retrospective review of 180 patients.//Cancer. 2005.V.104. N1. P.126-134.
Shim K.W., Park E.K., Lee Y.H., et al.Treatment strategy for intracranial primary pure germinoma.//Childs Nerv Syst. 2013. V.29. N2. P. 239-248.
Saeki N., Murai H, Kubota M., et al. Long-term Karnofsky performance status and neurological outcome in patients with neurohypophyseal germinomas.//Br J Neurosurg. 2001. V.15. N5. P.402-408.
Sakanaka K., Mizowaki T., Hiraoka M. Dosimetric advantage of intensity-modulated radiotherapy for whole ventricles in the treatment of localized intracranial germinoma.//Int J Radiat Oncol Biol Phys. 2012. V82. N2. P.273-280.
Sakanaka K., Mizowaki T., Sato S., Ogura K., Hiraoka M. Volumetric-modulated arc therapy vs conventional fixed-field intensity-modulated radiotherapy in a whole-ventricular irradiation: a planning comparison study.//Med Dosim. 2013.V 38. N2. P.204-208.
Schoenfeld G.O., Amdur R.J., Schmalfuss I.M., et al. Low-dose prophylactic craniospinal radiotherapy for intracranial germinoma.//Int J Radiat Oncol Biol Phys. 2006. V.65. N2. P.481-485.
Shibamoto Y., Abe M., Yamashita J., et al. Treatment results of intracranial germinoma as a function of the irradiated volume.//Int J Radiat Oncol Biol Phys. 1988. V.15. N2. P. 285290.
Shibamoto Y., Oda Y., Yamashita J., et al. The role of cerebrospinal fluid cytology in radiotherapy planning for intracranial germinoma.//Int J Radiat Oncol Biol Phys. 1994. V.29. N5. P.1089-1094.
Shibamoto Y., Takahashi M., Abe M. Reduction of the radiation dose for intracranial germinoma: a prospective study.//Br J Cancer. 1994. V.70. N5. P.984-989.
Shibamoto Y., Sasai K., Kokubo M., Hiraoka M. Salvage radiation therapy for intracranial germinoma recurring after primary chemotherapy.//J Neurooncol. 1999. V.44. N2. P.181-185.
Shin K.H., Kim I.H., Choe G. Impacts of elevated level of hCG in serum on clinical course and radiotherapy results in the histology-confirmed intracranial germinomas.//Acta Oncol. 2001. V.40. N1.P.98-101.
Smith A.A., Weng E., Handler M., Foreman N.K. Intracranial germ cell tumors: a single institution experience and review of the literature.//J Neurooncol. 2004. V.68. N2. P.153-159.
Strojan P., Zadravec L.Z., Anzic J., et al. The role of radiotherapy in the treatment of childhood intracranial germinoma: long-term survival and late effects.//Pediatr Blood Cancer. 2006. V.47. N1. P.77-82.
Tian C., Pu C., Wu W., Huang X., et al. Is biopsy needed to guide management for all patients with presumed intracranial ectopic germinomas.//J Neurooncol. 2009. V.92. N1. P.37-44.
Tseng C.K., Tsang N.M., Wei K.C., et al. Radiotherapy to primary CNS germinoma: how large an irradiated volume is justified for tumor control?//J Neurooncol. 2003. V.62. N3. P.343-348.
Tseng C.K., Tsang N.M., Jaing T.H., et al. Outcome of central nervous system germinoma treatment by chemoradiation.//J Pediatr Hematol Oncol. 2011. V.33. N4. P.138-142.
Ueba T., Yamashita K., Fujisawa I. et al. Long-term follow-up of 5 patients with intracranial germinomainitially treated by chemotherapy alone.//Acta Neurochir (Wien). 2007. V.149. N9. P.897-902.
Weksberg D.C., Shibamoto Y., Paulino A.C. Bifocal intracranial germinoma: a retrospective analysis of treatment outcomes in 20 patients and review of the literature.//Int J Radiat Oncol Biol Phys. 2012.V.82.N4. P.1341-1351.
Védrine L., Bauduceau O., Fayolle M., et al. Combined chemotherapy and radiation therapy for intracranial germinomas. The Val-de-Grace hospital experience.//Cancer Radiother. 2005. V.9. N5. P.335-340.
Yen S.H., Chen Y.W., Huang P.I., et al. Optimal treatment for intracranial germinoma: can we lower radiation dose without chemotherapy?//Int J Radiat Oncol Biol Phys. 2010. V.77. N4. P.980-987.
Zissiadis Y., Dutton S., Kieran M., et al. Stereotactic radiotherapy for pediatric intracranial germ cell tumors.//Int J Radiat Oncol Biol Phys. 2001. V. 51. N1. P. 108-112.

Еще

Статья научная