Metabolic processes in bone tissue under exposure to hyperthermia and administration of allogenic calcium-containing biomaterial "Lyoplast"
Автор: Pisareva E.V., Vlasov M.Y., Volova L.T., Ishchenko K.S., Sergeeva S.S.
Журнал: Вестник Воронежского государственного университета инженерных технологий @vestnik-vsuet
Рубрика: Пищевая биотехнология
Статья в выпуске: 1 (99) т.86, 2024 года.
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Stress increases the production of glucocorticoids, which enhance bone resorption processes. To treat bone tissue diseases, medicine uses drugs that regulate phosphorus-calcium metabolism. A promising biomaterial is a bone mineral component (BMC) of allogenic origin, containing hydroxyapatite and amorphous calcium phosphate, which enhances bone tissue regeneration. In this work the parameters of bone tissue metabolism were studied under daily stress exposure to high temperature and intramuscular administration of a suspension of bone mineral component “Lyoplast” to animals. There was an increase in cortisol and a decrease in alkaline phosphatase activity in the blood serum subjected to hyperthermia. Serum alkaline phosphatase activity in the hyperthermia group and the placebo group decreased by an average of 25%. The enzyme activity in animals that were injected with the bone component did not differ statistically from the control level. In animals exposed to hyperthermia due to the administration of a bone mineral component, the level of parathyroid hormone increased simultaneously with the calcitonin level. Serum parathyroid hormone levels were lower in the hyperthermia group than in the control one. А reciprocal relationship between two hormones, parathyroid hormone and calcitonin, has been established. Thus, the introduction of a suspension of the bone mineral component helps to reduce the intensity of osteoresorption. The use of biomaterial obtained by the original method helps to reduce the intensity of osteoresorption in the high-temperature model. With the introduction of a suspension of the bone mineral component, the osteodestructive effect of endogenous glucocorticoids is smoothed out and largely eliminated. Given the high potential for practical use of the bone mineral component, further research of its safety and effectiveness in other biological models is necessary with further implementation in clinical practice.
High temperature, mineral component, bone tissue, cortisol, alkaline phosphatase, parathyroid hormone, calcitonin, osteoresorption
Короткий адрес: https://sciup.org/140305685
IDR: 140305685 | DOI: 10.20914/2310-1202-2024-1-84-88
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