Metabolic and neurochemical changes in the brain under chronic stress and its correction with resveratrol and sertraline, in initially anxious behavior

When using a model of pre-adolescent chronic stress in sexually mature male Wistar rats with initially anxious behavior, features in metabolic and neurochemical processes in the brain were revealed. The main features defining initially anxious behavior and stress-induced changes were revealed by the results of the behavioral test “Elevated plus maze” (EPM). In chronic pre-stress, a slight decrease in the anxiety index, a decrease in the concentration of serotonin in the amygdala and hippocampus, and changes in the indicators of lipid peroxidation in brain tissues were found [1; 4] (Fig. 1-6). Intraperitoneal administration of resveratrol at a concentration of 50 mg/kg led to a significant increase in the anxiety index, which had a restless nature, and to the return of a number of neurochemical and metabolic indicators to control values [8; 21]. Combined use of sertraline with resveratrol (10 mg/kg, 50 mg/kg, respectively.