Mitochondrial therapy: direct visual assessment of the possibility of preventing myocardial infarction under chronic neurogenic pain and B16 melanoma growth in the experiment
Автор: Kit O.I., Shikhlyarova A.I., Frantsiyants E.M., Neskubina I.V., Kaplieva I.V., Zhukova G.V., Trepitaki L.K., Pogorelova Y.A., Bandovkina V.A., Surikova E.I., Popov I.A., Voronina T.N., Bykadorova O.V., Serdyukova E.V.
Журнал: Cardiometry @cardiometry
Рубрика: Review
Статья в выпуске: 22, 2022 года.
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On models of chronic neurogenic pain (CNP) and the growth of a malignant tumor (metastasizing B16 melanoma) in male mice, we studied an effect produced by mitochondrial therapy (MCT) on the state of the myocardium. Some structural correlates of the compensatory-restorative effect by mitochondria transplanted from healthy recipient rats were revealed. It has been identified that MCT contributes to the preservation of the structural integrity of the myocardial tissue, the inclusion of an auxiliary link in the cellular mechanisms of tissue restoration: fibroblasts, histiocytes, lymphocytes, eosinophils and other connective tissue elements, which implement the intercellular mechanism of information transfer that provides the external regulatory function of MCT. The ability of mitochondria to prevent the DNA decay determines the possibility of initiation of the operation of the nuclear mechanisms of the cardiomyocyte division, which is characteristic of a population of young cells and which indicates the determining position of exogenous mitochondria.
Laboratory mice, chronic neurogenic pain, b16 melanoma, mitochondrial therapy, myocardium, pathomorphology, cardiac microscopy
Короткий адрес: https://sciup.org/148324619
IDR: 148324619 | DOI: 10.18137/cardiometry.2022.22.3849
Список литературы Mitochondrial therapy: direct visual assessment of the possibility of preventing myocardial infarction under chronic neurogenic pain and B16 melanoma growth in the experiment
- Benjamin EJ, Blaha MJ, Chiuve SE. American Heart Association Statistics Committee and Stroke Statistics Subcommittee Heart disease and stroke statistics–2017 update: a report from the American Heart Association. Circulation. 2017;135:e146–e603.
- Shin B, et al. Novel Biological Strategy for Myocardial Protection by Intracoronary Delivery of Mitochondria: Safety and Efficacy. JACC. Basic to translational science. 2019;4(8);871–888. doi:10.1016/j.jacbts.2019.08.007.
- Zong WX, Rabinowitz JD, White E. Mitochondria and Cancer. Mol Cell. 2016; 61(5): 667–676. doi:10.1016/j. molcel.2016.02.011.
- Hall AR, Burke N, Dongworth RK, Hausenloy DJ. Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease. Br. J. Pharmacol. 2014;171:1890–1906. doi: 10.1111/bph.12516.
- Sun X, et al. Alda-1 treatment promotes the therapeutic effect of mitochondrial transplantation for myocardial ischemia-reperfusion injury. Bioactive materials. 2021;6(7):2058–2069. doi:10.1016/j.bioactmat. 2020.12.024.
- Potgieter M, Pretorius E, Pepper MS. Primary and secondary coenzyme Q10 deficiency: The role of therapeutic supplementation. Nutr. Rev. 2013;71:180–188. doi: 10.1111/nure.12011.
- El-Hattab AW, Zarante AM, Almannai M, Scaglia F. Therapies for mitochondrial diseases and current clinical trials. Mol. Genet. Metab. 2017;122:1–9. doi: 10.1016/j.ymgme.2017.09.009.
- Ponnusamy M, et al. Long noncoding RNA CPR (cardiomyocyte proliferation regulator) regulates cardiomyocyte proliferation and cardiac repair. Circulation. 2019;139:2668– 684.doi:10.1161/CIRCULATIONAHA.118.035832.
- Liu N, et al. Advances in 3D bioprinting technology for cardiac tissue engineering and regeneration. Bioact. Mater. 2021;6:1388–1401. doi: 10.1016/j.bioactmat. 2020.10.021.
- Wu Y, et al. Release of VEGF and BMP9 from injectable alginate based composite hydrogel for treatment of myocardial infarction. Bioact. Mater. 2021; 6:520–528. doi: 10.1016/j.bioactmat.2020.08.031.
- Kunecki M, Plazak W, Podolec P, Golba KS. Effects of endogenous cardioprotective mechanisms on ischemia-reperfusion injury. Postepy Hig. Med. Dosw. 2017;71:20–31. doi: 10.5604/17322693.1228267.
- Emani SM, et al. Autologous mitochondrial transplantation for dysfunction after ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2017;154:286–289. doi: 10.1016/j.jtcvs.2017.02.018.
- McCully JD, et al. Mitochondrial transplantation: from animal models to clinical use in humans. Mitochondrion. 2017;34:127–134. doi: 10.1016/j.mito.2017.03.004.
- Cowan DB, et al. Transit and integration of extracellular mitochondria in human heart cells. Sci Rep. 2017;7:17450. doi: 10.1038/s41598-017-17813-0.
- Kaza AK, Wamala I, Friehs I. Myocardial rescue with autologous mitochondrial transplantation in a porcine model of ischemia/reperfusion. J Thorac Cardiovasc Surg. 2017; 153:934–943. doi: 10.1016/j.jtcvs.2016.10.077.
- Park A, et al. Mitochondrial Transplantation as a Novel Therapeutic Strategy for Mitochondrial Diseases. International journal of molecular sciences. 2021; 22(9): 4793. https://doi.org/10.3390/ijms22094793.
- Frantsiyants EM, et al. The functional state of mitochondria of ca rdiomyocytes in a malignant process against the background of comorbid pathology in the experiment. South Russian journal of oncology. 2021;2( 3):13-22. doi: 10.37748/2686-9039-2021-2-32. [in Russian]
- Kit OI, et al. The effect of chronic neuropathic pain on the course of the malignant process of B16/F10 melanoma in male mice. News of higher educational institutions. North Caucasian region. Series: Natural Sciences. 2019; (201):106-111. doi: 10.23683/0321-3005-2019-1-106-111. [in Russian]
- Frantsiyants EM, et al. Content of apoptosis factors and self-organization processes in the mitochondria of heart cells in female mice C57BL/6 under growth of melanoma b16 / f10 linked with comorbid pathology. Cardiometry. 2021; 18:121-30.
- Kotieva IM, et al. An increase in the degree of malignancy of melanoma against the background of chronic pain in female mice. Malignant tumors. 2017; 7( 3S1): 123-4. [in Russian]
- Egorova MV, Afanasiev SA. Isolation of mitochondria from cells and tissues of animals and humans: Modern methodological techniques. Siberian medical journal. 2011; 26(1-1):22-28. [in Russian]
- Sarkisova DS. Structural bases of adaptation and compensation of disturbed functions. Мoscow, 1987. 445p. [in Russian]
- Atlas “Pathological morphology of the mouse”. 2010. V.3, 432p. [in Russian]
- Kit OI, et al. The processes of self-organization of mitochondria during the growth of experimental tumors under conditions of chronic neurogenic pain. News of higher educational institutions. North Caucasian region. Series: Natural Sciences. 2019; 2 (202):97-105. [in Russian]
- Frantsiyants ЕМ, et al. Effect of urokinase gene knockout on melanoma growth in experiment. Siberian scientific medical journal. 2019;39; 4:62-70. doi: 10.15372/SSMJ20190408. [in Russian]
- Frantsiyants ЕМ, et al. Vascular endothelial growth factors and receptors in the development of transplanted melanoma B16/F10. Russian journal of oncology. 2015. 20; 2:32-7. [in Russian]
- Kotieva IM, et al. Influence of chronic pain on the level of sex hormones, prolactin and gonadotropic hormones in blood serum and pathologically changed skin in female mice in the dynamics of malignant melanoma growth. News of higher educational institutions. North Caucasian region. Series: Natural Sciences. 2018; 2 (198):106-16. doi: 10.23683/0321-3005-2018-2-106-116. [in Russian]
- Kit ОI, et al. Neurotransmitter systems of the brain of female mice in the dynamics of the growth of malignant melanoma reproduced against the background of chronic pain. Pathogenesis. 2017; 15; 4:49-55. doi: 10.25557/GM.2018.4.9749. [in Russian]
- Kit ОI, et al. Dynamics of the tissue system of plasminogen regulators in skin melanoma against the background of chronic pain in female mice. Translational medicine. 2018. 5; 2:38-46. [in Russian]
- Lopez-Crisosto C, et al. Sarcoplasmic reticulum- mitochondria communication in cardiovascular pathophysiology. Nat. Rev. Cardiol. 2017; 14:342–360. doi: 10.1038/nrcardio.2017.23.
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