Review. Рубрика в журнале - Cardiometry
A review of work-life and well-being of parents
Статья научная
Purpose: The transition from office to work-from-home (WFH) has lead to an increased interest in the effects of this transition, not only on the quality of work obtained but also on the mental health of individuals. Research in this topic is expanding with different perspectives in focus. This review aims to identify the significant factors influenced by WFH and the consequential effects on working parents. Methodology: To write this review, 4 databases are being explored - SCOPUS, Emerald, EBSCO, and Web of Science. Papers reviewed are selected using the keywords work from home, well-being, mental health, work-life balance, and family combined with parents, family, working mother, or working father. The papers have been selected for the past 25 years. An attempt is being made to review at least 53 articles. Findings/Theoretical Implications: This paper will highlight the advantages and disadvantages parents face while balancing work and family. The review will give a comprehensive impression of the mental health state of working parents. Value: The study will enable future researchers to identify currently unexplored issues and design their studies based on the same.
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Activation therapy: theoretical and applied aspects
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The paper presents a brief review on how some concepts on the organism general adaptational reactions developed, including their role in increasing the unspecific resistance in the organism. Demonstrated is periodicity of the patterns of anti-stressor type reactions (training, calm and elevated activation) and stress in a wide range of stimulation values. The concepts on the organism adaptational reactions and reactivity levels have created the theoretical basis for practical applications of the activation therapy aimed at health improvement, prevention and treatment of various diseases, including oncology. Evidence data on the applications of the activation therapy as a promising approach to the organism state control are confirmed by the originators of this scientific discovery, their followers and medical experts.
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Application of bioinspired methods and means in medicine
Статья научная
This review examines the role of bioinspired methods in medicine and their potential for improving human health, as well as in the treatment of various diseases. The authors highlight the genetic algorithm and recommendation systems as one of the main tools used in bioinspired methods. This methodology is considered in various aspects of medical practice, such as diagnosis, therapy, prognosis, sports medicine and selection of the correct treatment. Various areas of application of bioinspired methods in medicine are considered. The authors provide an overview of research and development based on the principles of evolutionary modeling. In addition, ethical, economic, and legal aspects of the use of bioinspired methods in medicine are discussed. An integrated approach and a unique view on the role of bioinspired methods and means in medical practice is presented, which reflects modern views on the prospects for research and development of this area.
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Barriers to adoption of green buildings - a review
Статья научная
The global construction sector accounts for 13.2% of the world GDP. It contributes to the world’s economic growth engine and climate changes due to its high energy footprint. Sustainable buildings can reduce the adverse impacts of the construction industry, but their adoption is slow due to hindrances. The purpose of this paper is to extensively review the literature on barriers to green building adoption to date. Also, to highlight the overlapping and unique barriers specific to India compared to few prominent countries, provide solutions and recommendations for future research. The barriers were classified under Economic, Governmental, Organizational, and Social perception, Information, Technology, and material categories. Barriers unique to India and few others developing countries are an extension of project schedules, lack of research and developmental works, lack of public motivation, poor building code enforcement, high payback period, uncertain supply of green materials, improper implementation of policy framework, and performance of GBTs. The green building construction sector is fragmented around the world. Even green building definition is not the same globally, although the environmental aspect is the same. Similarly, there are unique and overlapping challenges in green building adoption globally. Buildings in usage perspectives can be classified into Residential and Non-residential. This study looks only at non-residential buildings due to their homogenous nature. There is a dearth of specific studies related to the adoption of green buildings in India. This study aims to fulfill India’s standing in the barriers to green building adoption concerning the developed and developing countries.
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Статья научная
The aim is to evaluate the physiological parameters of the efficacy of cardiac mitochondria transplantation in male mice with chronic neurogenic pain and B16/F10 melanoma growth. Materials and methods. Male mice (n=37) of the C57BL/6 line were used in the research work. The animals covered experimental groups as follows: mice with chronic neurogenic pain (CNP) + B16/F10 melanoma (n=27); mice with CNB + B16/ F10 melanoma + mitochondrial therapy (MC therapy) (n=10). Mitochondria were isolated from the heart of an intact rat with the use of differential centrifugation. An introduction of mitochondria to mice was carried out daily intraperitoneally at a dose of 3.3 mg of protein for 3 weeks. Statistical analysis of the results is carried out with the Statistica 10.0 software. Results. On day 21 (week 3) of the experiment, macroscopically in the melanoma tissue in the group of animals with MC therapy, there were 2.5 times more necrosis cases than in the group without MC therapy. During the examination of the internal organs, no metastases were detected in the animals treated with MC therapy, while in 100% of the animals without MC therapy metastases were found in the lungs and in 95% of them in the spleen. In the animals received MC therapy, there was no damage to the heart muscle in 75% of the cases, while in the group of the animals without MC therapy, the presence of lesions in the form of bruises on the surface of the heart was macroscopically detected in 100% of the animals. Conclusion. Thus, intraperitoneal transplantation of intact heart mitochondria contributed to the prevention of myocardial infarction and metastases to internal organs in the C57BL/6 male mice with B16/F10 melanoma growing against the background of chronic neurogenic pain.
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Biological rhythms in the living cell: tunes of the life
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Offered is an overview of the author's papers in exploring an interface between biological rhythms of energy, function and biosynthesis in a nerve cell of a crayfish stretch receptor. Parameters of mitochondrion aggregation rhythms integrally determine the energy metabolism in the cell. The level and the rhythms of aggregation of granular reticulum integrally reflect the regulation of biosynthesis in the body of the neuron cell. An influence of the functional activity on biosynthesis in the neuron soma and the influence of the pulse activity of the neuron are defined by rhythms of change in rates and density of flows of energy metabolism. An enhancement of the functional activity of a neuron corresponds to an increase in the rate of flow of energy produced, and an intensification of biosynthesis is linked with augmenting the energy flux density. The time lag in changing priorities in the energy regulation of the function and biosynthesis can explain variability of biological rhythm periods in a cell, the mechanism of the cell biological clock and an adaptation to the rhythms of the environment. Rhythms features of the function, biosynthesis and energetics are determined by a harmonization between the rhythms of sol-gel transitions in the cell compartments.
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Cardiotoxicity: a challenge for modern oncology
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The article provides a modern vision of the problem of cardiotoxicity in oncology. Integrity and generality of nodal pathogenetic events in the body in case of carcinogenesis, antitumor therapy and cardiopathology are caused by similar mechanisms at different hierarchical levels. Identity of potential risk factors, including inflammation, aging, obesity, diabetes and smoking, has been noted. Similarly, in the development of metabolic syndrome and carcinogenesis, the level of growth factors (IGF-1), neoangiogenesis, hormones and other triggers of oncological and cardiovascular pathology is increasing. It is important that a variety of clinical manifestations of cardiotoxicity are due to the rapid expansion of the number of therapeutic options for effects. This thesis is illustrated by vivid examples of the use of anthracycline-based drugs whose mechanism of action is aimed at damaging genetic targets. The use of monoclonal antibodies - trastuzumab, is directed against HER2 / ErB2 receptors in breast cancer and is accompanied by distinct signs of cardiotoxicity especially in the elderly...
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Статья научная
The 10th anniversary of the international journal CARDIOMETRY is a good opportunity to summarize achievements and highlight the important milestones in the life of the journal with respect to the contents of the journal associated with most advanced research information about the topical issues in cardiology and allied sciences biology and medicine. The ideas on a system-related approach and an integrative assessment of the actual organism status as a whole, which lay the foundation of the journal philosophy, allows covering as wide as possible a great variety of the aspect what is the norm and what is pathology that is a substantial prerequisite for delineating clearly structured themes treated by each issue of the journal and for making in such a manner a collection of the journal issues, with cardiology as a common thread, that distinguishes CARDIOMETRY from all other profiled scientific journals.
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Статья обзорная
This paper presents the results of a study in which cardiac signal of the first lead of a standard digital ECG system were processed. By filtering in the time domain, the cardiogram was clarified of noise that reduced influence of spectral harmonics by 10-15%. To present and classify frequency characteristics throughout the entire cardio signal, the QS section between the P and T peaks was smoothed. Due to the influence of sharp peaks on the results of spectral analysis, a result considerably differ from the sum of sinusoidal components is observed. The gap between the peaks is interpolated by the Lagrange polynomial since it did not show an influence on the resultant spectrum. The spectral representation revealed peaks with frequencies oddly even, 3.1 Hz and 6.2 Hz, corresponding to the P and T peaks. Based on the obtained results the frequencies corresponding to the remaining peaks of the cardiogram were also classified. The obtained results represent a spectrum of two regular harmonics what allows for further adequate diagnostics of ECG signals.
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Heart rate variability analysis: physiological foundations and main methods
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The article presents the main provisions of the methodology for the analysis of heart rate variability (HRV), which is now actively and widely implemented in many fields of medicine and applied physiology. This methodology was first developed in space medicine, where, already during the first manned spaceflights, there was a need in operative assessment of the person's reactions and abilities to maintain high performance and good level of health under different stress conditions. The HRV analysis methodology is based on the measurement of a consecutive series of cardiac cycle durations, for which electrocardiography, rheocardiography, ballistic cardiography, etc., can be used. The resulting numerical series are subjected to mathematical analysis using statistical, spectral and other methods. The results are interpreted as medical and physiological criteria of the functional state of the organism. Based on the mathematical model, a probabilistic approach to the prediction of pathological conditions was proposed...
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Hedonic hunger: eating for desire and not calories
Статья научная
Hedonic hunger can be described as a state where an individual experiences recurrent feelings, thoughts, and desires about food in the absence of energy deprivation. Living in an obesogenic environment where cheap, tasty foods are available in plentiful amounts is one of the major causes of hedonic hunger development. Hedonic hunger can be analyzed using a power of food scale (PFS) which estimates appetite and not palatable food consumption. The current epidemic of obesity globally (termed as “globesity” by WHO) is seen to be majorly driven by the hedonic eating system and an imbalance in the energy homeostasis system. Previous studies indicate that hedonic hunger and obesity are associated, and a weak but no significant correlation exists between BMI and PFS score. It can lead to the development of various lifestyle disorders in the longer run. High levels of pleasure- driven hunger can even lead to detrimental health outcomes like poor glycaemic control, unhealthy dietary behavior, and increased lipid profile levels which are aggravated explicitly in cardiovascular diseases. With the adaptation to western dietary lifestyle, people are keener to opt for food options that can be damaging and harmful when low levels of self-control, dietary motivation, and healthy dietary habits are absent. Apart from the reward regulation system, which has a direct effect on hedonic hunger, certain external factors like emotional eating, meals and meal preparation, food cravings, sleep, physical activity, stress, social media, portion size, peer influence, an atmosphere of a restaurant can also promote more than required intake of food. This review article summarizes the above findings taking into account the plethora of research studies conducted so far.
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Hierarchy of biological rhythms, chronodiagnostics and bio-feedback
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An overview of the author’s original works dedicated to the hierarchy of biological rhythms, chronodiagnostics and bio-controlled chronophysiotherapy is presented herein. Stability of biosystems is based on harmony of discrete spectra of their biological rhythms with a spectrum of normal cosmoheliogeophysical rhythms. According to the extent, the nature and the sort of the phase-related, systematic and hierarchical desynchronoses it is possible to diagnose and forecast the condition and the resistance of biosystems at their respective level. An efficient management of life is possible by bio-synchronization of an external physical action with the phases of increasing of energy supply for the respective responses of a biosystem. A prerequisite for bio-resonance is a multi-frequency parallel resonant capture. An invariant ratio of biological rhythms periods in their hierarchy explains an exclusive sensitivity of the biosystems to biologically significant information influences under their high noise immunity to influences having a single constant frequency or showing an abnormal range of frequencies. Chronodiagnostics identifies disorders (desynchronoses) at the early preclinical stage of a disease. Bio-controlled chronophysiotherapy allows eliminating not only the symptoms, but also the causes of diseases (desynchronoses) in an organism.
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Inseparable relationship between intellectual services and high-tech medical equipment
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The social problems in any country, related to public health and demography, induce developments and production of diagnostic and therapeutic medical equipment. Such equipment belongs to high-tech products and requires to be accompanied by intellectual services for a successful promotion of medical products on the market under modern competitive conditions. The authors hereof substantiate the need to develop intellectual services for companies manufacturing high-tech medical equipment. The article treats the concept of intellectual services, the peculiarities of the intellectual services market in Russia, the special features of high-tech medical products promotion, as well as instruments for promoting the intellectual services by high-tech medical equipment manufacturers.
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Justification for measurement equation: a fundamental issue in theoretical metrology
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A review and a critical analysis of the specialized literature on justification for the measurement equation and an estimation of a methodical error (uncertainty) of the measurement result are presented in the paper, and some prospects for solving of the issue are discussed herein.
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Mitochondrial therapy: a vision of the outlooks for treatment of main twenty-first-century diseases
Статья научная
Mitochondria are dynamic organelles which constantly change their shape, size, and location within the cells. Mitochondrial dynamics is associated with mesenchymal metabolism or epithelial-mesenchymal transition to regulate the stem cell differentiation, proliferation, migration, and apoptosis. The transfer of mitochondria from one cell to another is necessary to improve and maintain homeostasis in an organism. Mitochondrial transplantation is a therapeutic approach that involves an introduction of healthy mitochondria into damaged organs. Recent evidence data have shown that the physiological properties of healthy mitochondria provide their ability to replace damaged mitochondria, with suggesting that replacing damaged mitochondria with healthy mitochondria may protect cells from further damage. Moreover, mitochondria can also be actively released into the extracellular space and potentially be transferred between the cells in the central nervous system. This increased interest in mitochondrial therapy calls for a deeper understanding of the mechanisms, which build the basis for mitochondrial transfer, uptake, and cellular defense. In this review, questions related to the involvement of mitochondria in the pathogenesis of cancer will be discussed. Particular attention will be paid to mitochondrial transplantation as a therapeutic approach to treat the mitochondrial dysfunction under some pathological conditions.
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Статья научная
On models of chronic neurogenic pain (CNP) and the growth of a malignant tumor (metastasizing B16 melanoma) in male mice, we studied an effect produced by mitochondrial therapy (MCT) on the state of the myocardium. Some structural correlates of the compensatory-restorative effect by mitochondria transplanted from healthy recipient rats were revealed. It has been identified that MCT contributes to the preservation of the structural integrity of the myocardial tissue, the inclusion of an auxiliary link in the cellular mechanisms of tissue restoration: fibroblasts, histiocytes, lymphocytes, eosinophils and other connective tissue elements, which implement the intercellular mechanism of information transfer that provides the external regulatory function of MCT. The ability of mitochondria to prevent the DNA decay determines the possibility of initiation of the operation of the nuclear mechanisms of the cardiomyocyte division, which is characteristic of a population of young cells and which indicates the determining position of exogenous mitochondria.
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Статья обзорная
The present paper deals with prenosological diagnostics as methodology of an estimation of functional states of an organism. Highlighted is its first practical application in space medicine, at long influence of stressful factors, including such factor unusual to terrestrial organisms as weightlessness. Demonstrated is the methodology's wide recognition and use in various areas of medicine and physiology. Health is considered herein as process of the continuous adaptation of an organism to environment conditions. Thus, shown is the connection between transition from health to illness and decrease in adaptable possibilities. Transition from health to illness, an exhaustion and failure of mechanisms of adaptation are described in detail. The classification dividing the prenosological states into physiological norm, prenosological, premorbid and pathological states is used herein. Prenosological studies including diagnostics, screening and control are considered.
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Prospects for the use of neural networks in cardiometry
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This paper provides an overview of the use of neural network technology in cardiology, primarily in diagnostics using ECG. The aim of this work is to substantiate the use of artificial neural network technology in cardiometry, as a field of science that is closely related to cardiology, but differs from it in the wider use of natural science approaches. The definition of machine learning is given, and the concept of artificial neural networks as one of the methods of machine learning is defined. The mechanism of electrocardiogram recording is described and methods of its analysis are considered. The types of neural networks used for electrocardiograms processing are revealed. The prospects of using the neural network method for processing the data obtained during cardiometric studies are determined.
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Review of the recommender systems application in cardiology
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The article provides a review of the recommender systems application in medical field, cardiology, in particular. The concept of recommender systems is defined, the brief history of the recommender systems development is given. The main types of recommender systems and principles of their construction are presented. The advantages and disadvantages of the recommender system methods application in cardiology are identified. Methods for improving the recommender systems are proposed.
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