Мышечно-неинвазивный рак мочевого пузыря: современный взгляд на биомаркеры

Автор: Солодкий В.А., Павлов А.Ю., Дзидзария А.Г., Гафанов Р.А., Абдирахимов Л.А., Боженко В.К., Цаллагова З.С.

Журнал: Вестник Российского научного центра рентгенорадиологии Минздрава России @vestnik-rncrr

Статья в выпуске: 3 т.22, 2022 года.

Бесплатный доступ

Алгоритм принятия терапевтических решений для лечения больных с мышечно- неинвазивным рак мочевого пузыря (МНИРМП) по-прежнему является проблемой в клинической практике, поскольку прогностические биомаркеры ответа на лечение все еще находятся в стадии изучения. В дополнение к факторам риска, определенным EORTC, гистологические особенности также являются ключевыми переменными, способными повлиять на рецидив и прогрессирование рака мочевого пузыря. Как и мышечно-инвазивный рак, МНИРМП является гетерогенным заболеванием, характеризующимся геномной нестабильностью, различной скоростью мутаций и широким диапазоном экспрессии белков в тканях. В этом обзоре мы обобщили последние данные о прогностических и прогностически значимых тканевых биомаркерах при МНИРМП, помимо морфологических параметров, в плане их влияния на биологию опухоли и, следовательно, на ее поведение во время лечения. В обзоре приведены данные о наиболее распространенных молекулярных событиях, связанных с рецидивом и прогрессированием, а также обсуждена связь между доступными методами лечения и молекулярными факторами, которые могут предсказывать клинический ответ.

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Прогностический, биомаркер, мышечно-неинвазивный рак мочевого пузыря, рак мочевого пузыря, молекулярные подтипы, реакция бцж

Короткий адрес: https://sciup.org/149142270

IDR: 149142270

Список литературы Мышечно-неинвазивный рак мочевого пузыря: современный взгляд на биомаркеры

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