Directed osteoinduction for bone fibrous dysplasia

Purpose. To analyze the effectiveness of the technique of intramedullary reinforcement using wires with bioactive coating as hydroxylapatite (GA) of particular design for treatment of fibrous osteodysplasia. Material and Methods. The early clinical experience (9 children) summarized on surgical treatment of long bone fibrous dysplasia by the technique of intramedullary inducing bone tissue using wires with hydroxylapatite coating. The surgery technology described for the disease focal form and diffuse bone involvement complicated by a pathologic fracture. Results. A positive outcome of treatment achieved in all the patients without deformity recurrence with 5-year follow-up. Conclusion. Osteogenesis induction in the zone of fibrous dysplasia is the most rational stage of orthopaedics development. There is no need of pathologic focus radical resection – it’s enough to remove most of pathologic fibromatous tissue partially filling the cavity with bone autograft. The inducing coating of wires accelerates bone formation due to both the autograft and the changes in functioning osteogenic cells of immature bone tissue of which thin plates form in the cavities thereby bringing the ossification process to complete maturity.