Neurosurgical interventions in patients with cancer with cerebral metastases

Objectives. To study the results of treatment and analysis of the influence of various prognostic factors in patients with lung cancer with brain metastases to optimize the results of the neurosurgical stage of treatment and to identify the factors affecting the prognosis of the disease. Materials and methods. This study included 97 patients with morphologically verified histological diagnosis of metastasis of lung cancer in the brain. Morphological analysis showed adenocarcinoma in 66 % of patients (n = 64), squamous cell carcinoma - in 25,8 % (n = 25), small cell lung cancer - in 6,2 % (n = 6), large cell carcinoma - in 2 % of patients (n = 2). The mean age of patients was 54,66 years. Results. Various prognostic factors were analyzed. We revealed the dependence of the results of treatment from the period of development of metastatic lesions and from a variant of surgical technique in the removal of cerebral metastases. Indications and contraindications to neurosurgical interventions in patients with lung cancer with cerebral metastases were determined. Conclusion. Reasonable use of each stage in the complex treatment of patients with disseminated lung cancer, with an adequate assessment of prognostic factors, promotes stable remission with the preservation of functional activity.