Dynamics of hypercoagulable changes in the hemostasis system in patients with aplastic anemia in the presence of a clinically significant PNH clone

Aplastic anemia (AA) is a serious disease of the blood system, the etiology of which is unknown in 70% - 80% of cases. The main clinical symptom of the disease is bleeding. By itself, the group of patients with AA is heterogeneous not only in terms of the severity of the course, but also in terms of the pathogenesis of the disease. Thus, more than half of the patients in this group, using modern methods of diagnostics, can detect AA associated with paroxysmal nocturnal hemoglobinuria (AA/PNH) a cell phenotype characterized by disturbances in the coagulation system that contribute to increased thrombus formation, expressed in severe forms of the disease. In this regard, the study of the features of changes in the hemostasis system, both coagulation and platelet level, is of interest. The aim of this study was to compare the parameters of the hemostasis system in patients with AA without PNHclone, or having a minimal clone (up to 2%) with those of patients with a significant PNH clone (more than 25%) and in the group with PNH-clone > 90.