Clinical use of scaffold-technology to manage extensive bone defects

Introduction Practical application of regenerative medicine to restore structural and functional properties of damaged tissues and organs using bioactive implants could solve complex problems in contemporary traumatology and orthopedics. Objective To improve treatment results in posttraumatic diaphyseal defects of lower extremities. Material and Methods Treatment outcomes of 19 patients with posttraumatic bone defects of the femur and tibia that averaged of 8.8 ± 3.5 cm were studied. In the main group (9 patients), osteosynthesis of fragments was performed sequentially, first with external fixation and then with intramedullary nailing. Bone defect was bridged by a combination of a biomimetic tissue with a spongy autograft from the iliac wing. In the control group (10 patients), the Ilizarov method of non-free bone plasty was used. Results The results were studied after follow-up of two years. Bone defects were covered in all patients of both groups. However, in the main group, the physiological load on the limb was possible, on average, 7...