Specific features of acute myeloid leukemia treatment in old age patients.

The article describes a five-year experience of the Research institute of Hematology and Blood transfusion of the Republic of Uzbekistan on treatment in 26 oldage patients with acute myeloid leukemia. In this investigation was shown that from 6 patientsat the age of 60-69 years who received therapyaccording to protocol “5 + 2”, 4 (66.6 %) patientshas been achieved complete remission. Median disease-free survival was 25 + 13 month. In the subgroup of 9 patients with hard comorbidstatus of the age 60-69 who received small dosesof cytarabin (10mg/m2 twice per day 28 days), in4 (44.4 %) patients there was achieved complete remission. Median disease-free survival was60 + 48 month. In 6 (54.5 %) of 11 patients of 70years and older who treated with small doses ofcytarabine (28 days) the remission was achieved.Median disease-free survival was 13 + 7.5 month.Treatment of the patients of aged and senile age,on one hand, appeared to be a difficult task dueto severe somatic status, multiple accompanying diseases, high frequency of primary resistanceto treatment, and on the other hand, in the partof patients there may be achieved longtermoverall and relapsefree survival. The old age ofthe patient should not be reason for refusal fromperformance of cytostatic therapy.