Acute promyelocytic leukemia, which developed after cured lymphogranulomatosis according to the BEACOPP program, complicated by disseminated intravascular coagulation syndrome with venous thrombosis of the lower endpoints and thromboembolism of the pulmonary arteries

The article presents the results of clinical observation of a patient with acute promyelocytic leukemia (APL), which developed after the cure of lymphogranulomatosis according to the BEACOPPstandard program. The clinical course of the patient was characterized by pronounced manifestations of disseminated intravascular coagulation syndrome with thrombosis of the lower extremities and the iliac vein on the right, thromboembolism of two branches of the pulmonary arteries. The selected management tactics for this patient included the AIDA program aimed at suppressing blast infiltration of the bone marrow and, therefore, had not only an antitumor nature, but was also accompanied by an antithrombogenic effect. Anticoagulant therapy undertaken after an increase in platelet count, replacing the injectable form (enoxaparin) with the tablet form (apixaban). Clinical and hematological remission was obtained and the manifestations of thrombogenic complications significantly decreased