P-glikoprotein fermenti va uning dori preparatlarini metabolizmidagi roli
Автор: Tilakova Z.N.
Журнал: Экономика и социум @ekonomika-socium
Рубрика: Основной раздел
Статья в выпуске: 6-1 (85), 2021 года.
Бесплатный доступ
P-glikoprotein (P-gp) (ingl. permeability -o`tkazuvchanlik ) dori preparatlari (DP) lari metabolizmida ishtirok etuvchi transport oqsili bo`lib, u ATF ga bog`liq oqsil transporter hisoblanadi. Fermentning molekulyar og`irligi 170 kDa bo`lib, tarkibida 1280 ta aminokislota qoldig`i, uzunligi 136A, kengligi 70A bo`lgan 2 ta gomologik qismda guruhlangan. P-gp transport oqsili jigar, oshqozon, buyrakda va odam boshmiya endotelial hujayralarida sintezlanadi. Ferment turli hujayralarning sitoplazmatik membranalarida lokalizatsiya bo`lib, DP lari yoki ularning metabolitlarini hujayradan tashqariga chiqarish vazifasini bajaradi.
Dori preparatlari, p-glikoprotein, plazmatik membrana, metabolizm
Короткий адрес: https://sciup.org/140260602
IDR: 140260602
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