Human papillomavirus infection and possibilities of improving the effectiveness of therapy for recurrent anogenital warts

Introduction. In recent years, there has been an increase in the number of cases of anogenital warts, with localization in the urethra, which present significant difficulties in management tactics due to the high frequency of relapses, progression of clinical manifestations and damage to underlying tissues. According to a systematic review including PubMed and EMBASE data, severe anogenital warts may be associated with a decrease in local and systemic immunity, a decrease in the level of vitamin 25(OH)D and zinc in the blood serum. The search for methods to increase the effectiveness of therapy for anogenital warts is a very urgent problem. The aim of the study was to develop a method for increasing the effectiveness of combined therapy for recurrent anogenital warts. Materials and methods. The study included 25 men aged 24 to 50 years, with the diagnosis of recurrent anogenital warts. All patients had laboratory research in human papillomavirus (HPV) in scrapings; in sexually transmitted infections; determination of the level of 25(OH)D, zinc. The complex therapy included treatment with the extract of Solanum tuberosum (Panavir) in the form: Panavir solution, Panavir-gel, Panavir-Intim spray and topical use of imichimod and surgical destruction of genital warts. Results. Monitoring patients for 6 months showed the remission of 23 men, reccurent warts in the distal section of urethra - 2 patients. Conclusions. The study obtained the high efficiency of complex therapy with the inclusion of Solanum tuberosum and surgical treatment.